Detailed information of TA system TA126092

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3496416..3496641
• Replicon: chromosome
• Accession: NZ_CP040572
• Organism: Escherichia coli O157:H7 strain ECP17-46

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: FGA21_RS18465
• Protein ID: WP_000813263.1
• Coordinates: 3496416..3496571 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3496583..3496641 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGA21_RS18430	3491870..3492583	-	714	WP_000261909.1	helix-turn-helix domain-containing protein	-
FGA21_RS18435	3492721..3492917	-	197	Protein_3511	TrmB family transcriptional regulator	-
FGA21_RS18440	3493204..3494022	-	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
FGA21_RS18445	3494174..3494545	-	372	WP_000090264.1	antitermination protein	-
FGA21_RS18450	3494535..3494906	-	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
FGA21_RS18455	3494919..3495968	-	1050	WP_001265172.1	DUF968 domain-containing protein	-
FGA21_RS18460	3495970..3496248	-	279	WP_001341388.1	hypothetical protein	-
FGA21_RS18465	3496416..3496571	-	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
-	3496583..3496641	+	59	-	-	Antitoxin
FGA21_RS18485	3497176..3497949	+	774	WP_000160650.1	alpha/beta hydrolase	-
FGA21_RS18490	3498301..3498714	-	414	WP_001151233.1	DUF977 family protein	-
FGA21_RS18495	3498730..3499500	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
FGA21_RS18500	3499522..3500268	-	747	WP_000788745.1	ATP-binding protein	-
FGA21_RS18505	3500275..3501366	-	1092	WP_001205823.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T126092 WP_000813263.1 NZ_CP040572:c3496571-3496416 [Escherichia coli O157:H7]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T126092 NZ_CP040572:c3496571-3496416 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT126092 NZ_CP040572:3496583-3496641 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin