Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2534205..2534728 Replicon chromosome
Accession NZ_CP040560
Organism Staphylococcus aureus strain Col52-A5

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag FA001_RS13015 Protein ID WP_000074048.1
Coordinates 2534205..2534471 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag FA001_RS13020 Protein ID WP_000587616.1
Coordinates 2534471..2534728 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FA001_RS12995 2529512..2530699 - 1188 WP_000026194.1 MFS transporter -
FA001_RS13000 2531095..2531871 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
FA001_RS13005 2531864..2532526 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
FA001_RS13010 2532774..2533850 - 1077 WP_001076671.1 M42 family metallopeptidase -
FA001_RS13015 2534205..2534471 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
FA001_RS13020 2534471..2534728 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FA001_RS13030 2535087..2535542 + 456 WP_000732082.1 DUF1307 domain-containing protein -
FA001_RS13035 2535710..2537288 - 1579 Protein_2463 FMN-binding glutamate synthase family protein -
FA001_RS13040 2537483..2538232 + 750 WP_000072443.1 hypothetical protein -
FA001_RS13045 2538456..2539649 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T126028 WP_000074048.1 NZ_CP040560:c2534471-2534205 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T126028 NZ_CP040560:c2534471-2534205 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT126028 WP_000587616.1 NZ_CP040560:c2534728-2534471 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT126028 NZ_CP040560:c2534728-2534471 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References