Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2502705..2502889 Replicon chromosome
Accession NZ_CP040560
Organism Staphylococcus aureus strain Col52-A5

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag FA001_RS12875 Protein ID WP_000482650.1
Coordinates 2502782..2502889 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2502705..2502765 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FA001_RS12860 2498235..2498402 - 168 WP_031929627.1 hypothetical protein -
FA001_RS12865 2498633..2500366 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
FA001_RS12870 2500391..2502154 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2502705..2502765 + 61 - - Antitoxin
FA001_RS12875 2502782..2502889 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
FA001_RS12880 2503023..2503409 - 387 WP_000779358.1 flippase GtxA -
FA001_RS12885 2503677..2504819 + 1143 WP_001176863.1 glycerate kinase -
FA001_RS12890 2504879..2505538 + 660 WP_000831298.1 membrane protein -
FA001_RS12895 2505720..2506931 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
FA001_RS12900 2507054..2507527 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T126026 WP_000482650.1 NZ_CP040560:c2502889-2502782 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T126026 NZ_CP040560:c2502889-2502782 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT126026 NZ_CP040560:2502705-2502765 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References