Detailed information of TA system TA126017

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2038172..2038471
• Replicon: chromosome
• Accession: NZ_CP040560
• Organism: Staphylococcus aureus strain Col52-A5

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: FA001_RS10335
• Protein ID: WP_011447039.1
• Coordinates: 2038295..2038471 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2038172..2038227 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FA001_RS10290	2033503..2033763	+	261	WP_001791826.1	hypothetical protein	-
FA001_RS10295	2033816..2034166	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
FA001_RS10300	2034851..2035300	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
FA001_RS10305	2035395..2035730	-	336	Protein_1941	SH3 domain-containing protein	-
FA001_RS10315	2036380..2036871	-	492	WP_000920034.1	staphylokinase	-
FA001_RS10320	2037062..2037817	-	756	WP_000861038.1	CHAP domain-containing protein	-
FA001_RS10325	2037829..2038083	-	255	WP_000611512.1	phage holin	-
FA001_RS10330	2038135..2038242	+	108	WP_001791821.1	hypothetical protein	-
-	2038164..2038303	+	140	NuclAT_0	-	-
-	2038164..2038303	+	140	NuclAT_0	-	-
-	2038164..2038303	+	140	NuclAT_0	-	-
-	2038164..2038303	+	140	NuclAT_0	-	-
-	2038172..2038227	+	56	-	-	Antitoxin
FA001_RS10335	2038295..2038471	-	177	WP_011447039.1	putative holin-like toxin	Toxin
FA001_RS10340	2038621..2038917	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
FA001_RS10345	2038975..2039262	-	288	WP_001040261.1	hypothetical protein	-
FA001_RS10350	2039309..2039461	-	153	WP_001153681.1	hypothetical protein	-
FA001_RS10355	2039451..2043236	-	3786	WP_000582137.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2033816..2089654	55838

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T126017 WP_011447039.1 NZ_CP040560:c2038471-2038295 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T126017 NZ_CP040560:c2038471-2038295 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT126017 NZ_CP040560:2038172-2038227 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin