Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 53338..53602 Replicon plasmid pCR-HvKP1-p3
Accession NZ_CP040536
Organism Klebsiella pneumoniae strain CR-HvKP1

Toxin (Protein)


Gene name pndA Uniprot ID E6BRV3
Locus tag FFT47_RS29480 Protein ID WP_001303307.1
Coordinates 53450..53602 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 53338..53400 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFT47_RS29465 49440..50510 - 1071 WP_000151582.1 IncI1-type conjugal transfer protein TrbB -
FFT47_RS29470 50529..51737 - 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
- 51917..51977 - 61 NuclAT_1 - -
- 51917..51977 - 61 NuclAT_1 - -
- 51917..51977 - 61 NuclAT_1 - -
- 51917..51977 - 61 NuclAT_1 - -
FFT47_RS29475 52044..53135 - 1092 WP_000426061.1 hypothetical protein -
- 53338..53400 - 63 NuclAT_0 - Antitoxin
- 53338..53400 - 63 NuclAT_0 - Antitoxin
- 53338..53400 - 63 NuclAT_0 - Antitoxin
- 53338..53400 - 63 NuclAT_0 - Antitoxin
FFT47_RS29480 53450..53602 + 153 WP_001303307.1 Hok/Gef family protein Toxin
FFT47_RS29485 53674..53925 - 252 WP_001291968.1 hypothetical protein -
- 54312..54363 - 52 NuclAT_2 - -
- 54312..54363 - 52 NuclAT_2 - -
- 54312..54363 - 52 NuclAT_2 - -
- 54312..54363 - 52 NuclAT_2 - -
FFT47_RS30585 54849..55025 - 177 WP_001054900.1 hypothetical protein -
FFT47_RS29500 55234..55443 - 210 WP_001140545.1 hemolysin expression modulator Hha -
FFT47_RS29505 55541..56155 - 615 WP_000578649.1 plasmid IncI1-type surface exclusion protein ExcA -
FFT47_RS29510 56231..58399 - 2169 WP_000698360.1 IncI1-type conjugal transfer membrane protein TraY -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..99717 99717


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-46)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5817.21 Da        Isoelectric Point: 8.7948

>T125942 WP_001303307.1 NZ_CP040536:53450-53602 [Klebsiella pneumoniae]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T125942 NZ_CP040536:53450-53602 [Klebsiella pneumoniae]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 63 bp

>AT125942 NZ_CP040536:c53400-53338 [Klebsiella pneumoniae]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A634Q5L1


Antitoxin

Download structure file

References