Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1293448..1294045 Replicon chromosome
Accession NZ_CP040511
Organism Acidithiobacillus ferrooxidans strain YNTRS-40

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FE661_RS06635 Protein ID WP_054608787.1
Coordinates 1293448..1293726 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FE661_RS06640 Protein ID WP_054608786.1
Coordinates 1293743..1294045 (+) Length 101 a.a.

Genomic Context

FE661_RS06635FE661_RS06640FE661_RS06655FE661_RS06660FE661_RS06665FE661_RS06615FE661_RS06620FE661_RS06625FE661_RS06630FE661_RS06645FE661_RS06650FE661_RS06670
Location: 1293448..1293726 (279 bp)
Type: Toxin
Protein ID: WP_054608787.1
Location: 1293743..1294045 (303 bp)
Type: Antitoxin
Protein ID: WP_054608786.1
Location: 1296495..1296767 (273 bp)
Type: Others
Protein ID: WP_054608783.1
Location: 1296794..1297060 (267 bp)
Type: Others
Protein ID: WP_054608782.1
Location: 1297131..1297553 (423 bp)
Type: Others
Protein ID: WP_054608781.1
Location: 1288526..1290601 (2076 bp)
Type: Others
Protein ID: WP_157293188.1
Location: 1290582..1290761 (180 bp)
Type: Others
Protein ID: WP_146235814.1
Location: 1290901..1291755 (855 bp)
Type: Others
Protein ID: WP_054608789.1
Location: 1291840..1293291 (1452 bp)
Type: Others
Protein ID: WP_054608788.1
Location: 1294064..1296001 (1938 bp)
Type: Others
Protein ID: WP_054608785.1
Location: 1296001..1296327 (327 bp)
Type: Others
Protein ID: WP_054608784.1
Location: 1297672..1298778 (1107 bp)
Type: Others
Protein ID: WP_054608857.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FE661_RS066151288526..1290601-2076WP_157293188.1DUF1738 domain-containing protein-
FE661_RS066201290582..1290761-180WP_146235814.1hypothetical protein-
FE661_RS066251290901..1291755-855WP_054608789.1DNA adenine methylase-
FE661_RS066301291840..1293291-1452WP_054608788.1toprim domain-containing protein-
FE661_RS066351293448..1293726+279WP_054608787.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FE661_RS066401293743..1294045+303WP_054608786.1HigA family addiction module antidote proteinAntitoxin
FE661_RS066451294064..1296001-1938WP_054608785.1relaxase/mobilization nuclease domain-containing protein-
FE661_RS066501296001..1296327-327WP_054608784.1hypothetical protein-
FE661_RS066551296495..1296767+273WP_054608783.1HU family DNA-binding protein-
FE661_RS066601296794..1297060+267WP_054608782.1superinfection immunity protein-
FE661_RS066651297131..1297553+423WP_054608781.1hypothetical protein-
FE661_RS066701297672..1298778-1107WP_054608857.1cellulase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-92)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10745.15 Da        Isoelectric Point: 7.8253

>T125878 WP_054608787.1 NZ_CP040511:1293448-1293726 [Acidithiobacillus ferrooxidans]
MIKSFRCKDTQSLFEGGAPRRFQGVRPQAERKLLMVDSAKDLKDLKSPPGNGLEKLSGDRKDQWSIRINDQWRICFDWRD
GDAYDVEIVDYH

Download         Length: 279 bp

>T125878 NZ_CP040511:1293448-1293726 [Acidithiobacillus ferrooxidans]
ATGATCAAGTCTTTCCGTTGCAAGGATACGCAAAGCCTGTTTGAAGGCGGGGCACCGCGCCGATTTCAGGGGGTCAGGCC
CCAAGCCGAGCGGAAGCTGTTGATGGTGGATTCGGCGAAGGATCTGAAGGACTTGAAAAGCCCGCCGGGTAACGGCTTAG
AGAAGCTCTCCGGAGACCGCAAAGATCAGTGGAGCATTCGTATCAACGACCAGTGGCGAATATGCTTCGATTGGCGAGAT
GGCGATGCGTATGACGTTGAAATCGTGGATTACCATTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11439.21 Da        Isoelectric Point: 10.8303

>AT125878 WP_054608786.1 NZ_CP040511:1293743-1294045 [Acidithiobacillus ferrooxidans]
MTRNRMRPIHPGEVLREEFLAPLGMTPHALAVALRVPSPRINDITRERRAITPDTALRLARYFGTTPEFWMELQSVYDLR
RAEVIAGESISREVTPRQAA

Download         Length: 303 bp

>AT125878 NZ_CP040511:1293743-1294045 [Acidithiobacillus ferrooxidans]
ATGACTAGAAACAGGATGCGCCCGATTCACCCTGGCGAAGTGTTGCGCGAGGAGTTTTTGGCCCCGCTGGGTATGACGCC
CCATGCGTTGGCGGTCGCGTTGCGCGTACCATCACCGCGCATCAATGACATAACGCGGGAACGGCGGGCGATTACGCCGG
ATACTGCCTTGCGGCTGGCCCGCTATTTCGGGACGACCCCGGAATTCTGGATGGAACTGCAGAGTGTTTATGACCTGCGC
AGGGCTGAGGTTATCGCCGGTGAGTCTATCTCTCGTGAGGTGACCCCGCGGCAGGCGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References