Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1293448..1294045 Replicon chromosome
Accession NZ_CP040511
Organism Acidithiobacillus ferrooxidans strain YNTRS-40

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FE661_RS06635 Protein ID WP_054608787.1
Coordinates 1293448..1293726 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FE661_RS06640 Protein ID WP_054608786.1
Coordinates 1293743..1294045 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE661_RS06615 1288526..1290601 - 2076 WP_157293188.1 DUF1738 domain-containing protein -
FE661_RS06620 1290582..1290761 - 180 WP_146235814.1 hypothetical protein -
FE661_RS06625 1290901..1291755 - 855 WP_054608789.1 DNA adenine methylase -
FE661_RS06630 1291840..1293291 - 1452 WP_054608788.1 toprim domain-containing protein -
FE661_RS06635 1293448..1293726 + 279 WP_054608787.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FE661_RS06640 1293743..1294045 + 303 WP_054608786.1 HigA family addiction module antidote protein Antitoxin
FE661_RS06645 1294064..1296001 - 1938 WP_054608785.1 relaxase/mobilization nuclease domain-containing protein -
FE661_RS06650 1296001..1296327 - 327 WP_054608784.1 hypothetical protein -
FE661_RS06655 1296495..1296767 + 273 WP_054608783.1 HU family DNA-binding protein -
FE661_RS06660 1296794..1297060 + 267 WP_054608782.1 superinfection immunity protein -
FE661_RS06665 1297131..1297553 + 423 WP_054608781.1 hypothetical protein -
FE661_RS06670 1297672..1298778 - 1107 WP_054608857.1 cellulase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-92)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10745.15 Da        Isoelectric Point: 7.8253

>T125878 WP_054608787.1 NZ_CP040511:1293448-1293726 [Acidithiobacillus ferrooxidans]
MIKSFRCKDTQSLFEGGAPRRFQGVRPQAERKLLMVDSAKDLKDLKSPPGNGLEKLSGDRKDQWSIRINDQWRICFDWRD
GDAYDVEIVDYH

Download         Length: 279 bp

>T125878 NZ_CP040511:1293448-1293726 [Acidithiobacillus ferrooxidans]
ATGATCAAGTCTTTCCGTTGCAAGGATACGCAAAGCCTGTTTGAAGGCGGGGCACCGCGCCGATTTCAGGGGGTCAGGCC
CCAAGCCGAGCGGAAGCTGTTGATGGTGGATTCGGCGAAGGATCTGAAGGACTTGAAAAGCCCGCCGGGTAACGGCTTAG
AGAAGCTCTCCGGAGACCGCAAAGATCAGTGGAGCATTCGTATCAACGACCAGTGGCGAATATGCTTCGATTGGCGAGAT
GGCGATGCGTATGACGTTGAAATCGTGGATTACCATTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11439.21 Da        Isoelectric Point: 10.8303

>AT125878 WP_054608786.1 NZ_CP040511:1293743-1294045 [Acidithiobacillus ferrooxidans]
MTRNRMRPIHPGEVLREEFLAPLGMTPHALAVALRVPSPRINDITRERRAITPDTALRLARYFGTTPEFWMELQSVYDLR
RAEVIAGESISREVTPRQAA

Download         Length: 303 bp

>AT125878 NZ_CP040511:1293743-1294045 [Acidithiobacillus ferrooxidans]
ATGACTAGAAACAGGATGCGCCCGATTCACCCTGGCGAAGTGTTGCGCGAGGAGTTTTTGGCCCCGCTGGGTATGACGCC
CCATGCGTTGGCGGTCGCGTTGCGCGTACCATCACCGCGCATCAATGACATAACGCGGGAACGGCGGGCGATTACGCCGG
ATACTGCCTTGCGGCTGGCCCGCTATTTCGGGACGACCCCGGAATTCTGGATGGAACTGCAGAGTGTTTATGACCTGCGC
AGGGCTGAGGTTATCGCCGGTGAGTCTATCTCTCGTGAGGTGACCCCGCGGCAGGCGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References