Detailed information of TA system TA125870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 4475286..4475997
• Replicon: chromosome
• Accession: NZ_CP040506
• Organism: Hungatella hathewayi WAL-18680

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FFD75_RS20400
• Protein ID: WP_198138515.1
• Coordinates: 4475286..4475672 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FFD75_RS20405
• Protein ID: WP_006778850.1
• Coordinates: 4475659..4475997 (+)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFD75_RS20380	4470926..4472317	+	1392	WP_006778845.1	ABC transporter substrate-binding protein	-
FFD75_RS20385	4472363..4473271	+	909	WP_006778846.1	sugar ABC transporter permease	-
FFD75_RS20390	4473284..4474165	+	882	WP_006778847.1	carbohydrate ABC transporter permease	-
FFD75_RS20395	4474218..4474940	+	723	WP_006778848.1	glycerophosphodiester phosphodiesterase	-
FFD75_RS20400	4475286..4475672	+	387	WP_198138515.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FFD75_RS20405	4475659..4475997	+	339	WP_006778850.1	helix-turn-helix transcriptional regulator	Antitoxin
FFD75_RS20410	4476232..4476420	+	189	WP_080568780.1	type II toxin-antitoxin system HicA family toxin	-
FFD75_RS20415	4476469..4476921	+	453	WP_006778851.1	type II toxin-antitoxin system HicB family antitoxin	-
FFD75_RS20420	4477182..4477625	+	444	WP_006778852.1	hypothetical protein	-
FFD75_RS20425	4477819..4479150	+	1332	WP_006778853.1	sugar ABC transporter substrate-binding protein	-
FFD75_RS20430	4479214..4480077	+	864	WP_198138522.1	sugar ABC transporter permease	-
FFD75_RS20435	4480085..4480924	+	840	WP_006778855.1	carbohydrate ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (41-115)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-88)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15130.46 Da
• Isoelectric Point: 10.2489

>T125870 WP_198138515.1 NZ_CP040506:4475286-4475672 [Hungatella hathewayi WAL-18680]
MNGGKDLHEIIFYRDSKGREPVLNYLRELSGRHDKDSRIKLNKISDYIQALSMYGCQLNENYVKHLEGEIWELRPMKNRI
LFAGIVGGRYVLLHQFQKRTRKTPAREIEKAKRELADFKKRSGFYEGI

Nucleotide

• Length: 387 bp

>T125870 NZ_CP040506:4475286-4475672 [Hungatella hathewayi WAL-18680]
ATGAATGGAGGAAAAGATTTGCACGAGATTATTTTTTATCGCGACAGCAAAGGCAGGGAACCAGTTTTGAATTATTTGAG
GGAATTAAGTGGACGTCATGATAAAGACAGCCGAATCAAATTAAACAAGATTAGTGATTACATACAGGCATTAAGTATGT
ATGGTTGTCAATTGAATGAAAACTATGTGAAGCATTTAGAGGGCGAAATATGGGAATTGCGTCCGATGAAAAACCGGATT
TTATTCGCCGGAATTGTTGGTGGACGGTATGTTCTGCTTCATCAGTTTCAAAAACGGACACGAAAGACGCCTGCTAGAGA
GATAGAAAAGGCAAAACGGGAACTGGCAGATTTTAAGAAAAGGAGCGGTTTTTATGAAGGAATTTAG

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12380.39 Da
• Isoelectric Point: 9.8400

>AT125870 WP_006778850.1 NZ_CP040506:4475659-4475997 [Hungatella hathewayi WAL-18680]
MKEFSSVGTSWEEARKELLTPEEIAESDLRVALIGEIMKIRQEQGISQRQLEKKSGVKQPVIARMEHGTTIPSLSTVLKV
LVALGKTLYIGDLDTKNAAGKTVLGEKPYKNK

Nucleotide

• Length: 339 bp

>AT125870 NZ_CP040506:4475659-4475997 [Hungatella hathewayi WAL-18680]
ATGAAGGAATTTAGTTCGGTTGGTACCTCATGGGAAGAGGCACGGAAAGAACTGCTTACCCCTGAGGAGATTGCGGAAAG
CGATTTAAGGGTAGCGCTGATTGGTGAAATTATGAAGATAAGACAGGAGCAGGGAATATCACAAAGACAATTGGAGAAGA
AAAGTGGGGTGAAGCAGCCAGTGATTGCAAGAATGGAACATGGCACGACTATTCCTAGTTTAAGTACGGTGCTCAAGGTG
CTGGTGGCTCTGGGGAAAACACTTTACATTGGAGATTTGGATACTAAAAATGCAGCCGGAAAGACGGTTCTTGGAGAAAA
ACCATATAAAAATAAGTGA