Detailed information of TA system TA125860

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4324605..4325017
• Replicon: chromosome
• Accession: NZ_CP040456
• Organism: Escherichia coli strain UPEC132

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: FE252_RS22710
• Protein ID: WP_000132601.1
• Coordinates: 4324676..4325017 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4324605..4324681 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE252_RS22700	4321468..4323057	+	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-
FE252_RS22705	4323054..4324448	+	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
-	4324605..4324681	-	77	NuclAT_5	-	Antitoxin
-	4324605..4324681	-	77	NuclAT_5	-	Antitoxin
-	4324605..4324681	-	77	NuclAT_5	-	Antitoxin
-	4324605..4324681	-	77	NuclAT_5	-	Antitoxin
-	4324605..4324681	-	77	NuclAT_6	-	Antitoxin
-	4324605..4324681	-	77	NuclAT_6	-	Antitoxin
-	4324605..4324681	-	77	NuclAT_6	-	Antitoxin
-	4324605..4324681	-	77	NuclAT_6	-	Antitoxin
FE252_RS22710	4324676..4325017	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
FE252_RS22715	4325179..4326558	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
FE252_RS22720	4326558..4327604	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T125860 WP_000132601.1 NZ_CP040456:4324676-4325017 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T125860 NZ_CP040456:4324676-4325017 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT125860 NZ_CP040456:c4324681-4324605 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCAGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin