125858

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4242832..4243090 Replicon chromosome
Accession NZ_CP040456
Organism Escherichia coli strain UPEC132

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag FE252_RS22320 Protein ID WP_000809168.1
Coordinates 4242938..4243090 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4242832..4242889 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE252_RS22305 4238661..4239920 - 1260 WP_000494928.1 hypothetical protein -
FE252_RS22310 4240049..4241542 - 1494 WP_001468392.1 sulfatase-like hydrolase/transferase -
FE252_RS22315 4241562..4242323 - 762 WP_001274832.1 hypothetical protein -
- 4242832..4242889 - 58 - - Antitoxin
FE252_RS22320 4242938..4243090 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
FE252_RS22325 4243195..4244325 - 1131 WP_001118464.1 molecular chaperone DnaJ -
FE252_RS22330 4244414..4246330 - 1917 WP_000516135.1 molecular chaperone DnaK -
FE252_RS22335 4246703..4247107 + 405 WP_000843687.1 DUF2541 family protein -
FE252_RS22340 4247133..4247846 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T125858 WP_000809168.1 NZ_CP040456:4242938-4243090 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T125858 NZ_CP040456:4242938-4243090 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT125858 NZ_CP040456:c4242889-4242832 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References