Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1988808..1989310 Replicon chromosome
Accession NZ_CP040456
Organism Escherichia coli strain UPEC132

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag FE252_RS11075 Protein ID WP_000767829.1
Coordinates 1989056..1989310 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag FE252_RS11070 Protein ID WP_001259255.1
Coordinates 1988808..1989059 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE252_RS11040 1983986..1985053 - 1068 WP_000080068.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
FE252_RS11045 1985053..1986123 - 1071 WP_001099222.1 histidinol-phosphate transaminase -
FE252_RS11050 1986120..1987424 - 1305 WP_001468360.1 histidinol dehydrogenase -
FE252_RS11055 1987430..1988329 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
FE252_RS11060 1988475..1988525 - 51 WP_001364200.1 his operon leader peptide -
FE252_RS11070 1988808..1989059 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
FE252_RS11075 1989056..1989310 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
FE252_RS11080 1989393..1990217 + 825 WP_000754734.1 SDR family oxidoreductase -
FE252_RS11085 1990263..1991192 + 930 WP_000803351.1 LysR family transcriptional regulator -
FE252_RS11090 1991407..1991469 + 63 WP_010723108.1 membrane protein YoeI -
FE252_RS11095 1991459..1992817 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
FE252_RS11100 1992996..1994054 + 1059 WP_000492321.1 transport protein YeeE -
FE252_RS11105 1994068..1994295 + 228 WP_000985267.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T125843 WP_000767829.1 NZ_CP040456:1989056-1989310 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T125843 NZ_CP040456:1989056-1989310 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCAGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT125843 WP_001259255.1 NZ_CP040456:1988808-1989059 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT125843 NZ_CP040456:1988808-1989059 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAGGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCTGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References