125843

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1988808..1989310 Replicon chromosome
Accession NZ_CP040456
Organism Escherichia coli strain UPEC132

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag FE252_RS11075 Protein ID WP_000767829.1
Coordinates 1989056..1989310 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag FE252_RS11070 Protein ID WP_001259255.1
Coordinates 1988808..1989059 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE252_RS11040 1983986..1985053 - 1068 WP_000080068.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
FE252_RS11045 1985053..1986123 - 1071 WP_001099222.1 histidinol-phosphate transaminase -
FE252_RS11050 1986120..1987424 - 1305 WP_001468360.1 histidinol dehydrogenase -
FE252_RS11055 1987430..1988329 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
FE252_RS11060 1988475..1988525 - 51 WP_001364200.1 his operon leader peptide -
FE252_RS11070 1988808..1989059 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
FE252_RS11075 1989056..1989310 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
FE252_RS11080 1989393..1990217 + 825 WP_000754734.1 SDR family oxidoreductase -
FE252_RS11085 1990263..1991192 + 930 WP_000803351.1 LysR family transcriptional regulator -
FE252_RS11090 1991407..1991469 + 63 WP_010723108.1 membrane protein YoeI -
FE252_RS11095 1991459..1992817 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
FE252_RS11100 1992996..1994054 + 1059 WP_000492321.1 transport protein YeeE -
FE252_RS11105 1994068..1994295 + 228 WP_000985267.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T125843 WP_000767829.1 NZ_CP040456:1989056-1989310 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T125843 NZ_CP040456:1989056-1989310 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCAGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT125843 WP_001259255.1 NZ_CP040456:1988808-1989059 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT125843 NZ_CP040456:1988808-1989059 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAGGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCTGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References