Detailed information of TA system TA125838

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 226230..226452
• Replicon: chromosome
• Accession: NZ_CP040456
• Organism: Escherichia coli strain UPEC132

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A0D6GD35
• Locus tag: FE252_RS02635
• Protein ID: WP_000170745.1
• Coordinates: 226345..226452 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	226230..226288 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE252_RS02610	221671..222573	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
FE252_RS02615	222584..223567	+	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
FE252_RS02620	223564..224568	+	1005	WP_000103583.1	dipeptide ABC transporter ATP-binding subunit DppF	-
FE252_RS02625	224598..225869	-	1272	WP_001467807.1	amino acid permease	-
-	226230..226288	-	59	-	-	Antitoxin
FE252_RS02635	226345..226452	+	108	WP_000170745.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
FE252_RS02640	226539..228218	-	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
FE252_RS02645	228215..228406	-	192	WP_000988311.1	cellulose biosynthesis protein BcsF	-
FE252_RS02650	228403..229974	-	1572	WP_001204945.1	cellulose biosynthesis protein BcsE	-
FE252_RS02655	230247..230435	+	189	WP_001063314.1	YhjR family protein	-
FE252_RS02660	230447..231199	+	753	WP_000279525.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3855.68 Da
• Isoelectric Point: 9.0157

>T125838 WP_000170745.1 NZ_CP040456:226345-226452 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVSWLNKRK

Nucleotide

• Length: 108 bp

>T125838 NZ_CP040456:226345-226452 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT125838 NZ_CP040456:c226288-226230 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A0D6GD35

Antitoxin