Detailed information of TA system TA125830

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 41553..41806
• Replicon: plasmid unnamed1
• Accession: NZ_CP040454
• Organism: Escherichia coli strain UPEC132

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: A0A148HBD8
• Locus tag: FE252_RS00245
• Protein ID: WP_001336447.1
• Coordinates: 41553..41702 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	41750..41806 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE252_RS00195	37357..38004	+	648	WP_021515401.1	hypothetical protein	-
FE252_RS00200	38229..38528	-	300	WP_021515402.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FE252_RS00205	38518..38781	-	264	WP_001089474.1	hypothetical protein	-
FE252_RS00210	38888..39148	-	261	WP_024187481.1	hypothetical protein	-
FE252_RS00225	39851..40708	-	858	WP_145747938.1	incFII family plasmid replication initiator RepA	-
FE252_RS00230	40701..40775	-	75	WP_001365705.1	RepA leader peptide Tap	-
FE252_RS00240	41011..41268	-	258	WP_000084404.1	replication regulatory protein RepA	-
FE252_RS00245	41553..41702	-	150	WP_001336447.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	41750..41806	+	57	NuclAT_1	-	Antitoxin
-	41750..41806	+	57	NuclAT_1	-	Antitoxin
-	41750..41806	+	57	NuclAT_1	-	Antitoxin
-	41750..41806	+	57	NuclAT_1	-	Antitoxin
FE252_RS00255	41901..42338	-	438	WP_000872609.1	hypothetical protein	-
FE252_RS27395	42491..42875	-	385	Protein_41	hypothetical protein	-
FE252_RS00270	42978..43439	-	462	WP_145747939.1	thermonuclease family protein	-
FE252_RS00275	44181..44384	-	204	WP_001336517.1	hypothetical protein	-
FE252_RS00280	44536..45093	-	558	WP_000139329.1	fertility inhibition protein FinO	-
FE252_RS00285	45148..45894	-	747	WP_113318688.1	conjugal transfer pilus acetylase TraX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	senB	1..117139	117139

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (4-45)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5572.69 Da
• Isoelectric Point: 8.7678

>T125830 WP_001336447.1 NZ_CP040454:c41702-41553 [Escherichia coli]
MTKYTLIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 150 bp

>T125830 NZ_CP040454:c41702-41553 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 57 bp

>AT125830 NZ_CP040454:41750-41806 [Escherichia coli]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A148HBD8

Antitoxin