Detailed information of TA system TA125814

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2988142..2988400
• Replicon: chromosome
• Accession: NZ_CP040443
• Organism: Escherichia sp. E4742

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: FEM44_RS14595
• Protein ID: WP_000935262.1
• Coordinates: 2988142..2988351 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	2988343..2988400 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEM44_RS14575	2983384..2984097	-	714	WP_135523742.1	acidic protein MsyB	-
FEM44_RS14580	2984123..2984527	-	405	WP_135523743.1	DUF2541 family protein	-
FEM44_RS14585	2984902..2986818	+	1917	WP_000516135.1	molecular chaperone DnaK	-
FEM44_RS14590	2986907..2988037	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
FEM44_RS14595	2988142..2988351	-	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	2988343..2988400	+	58	-	-	Antitoxin
FEM44_RS14600	2988879..2990045	+	1167	WP_000681376.1	Na+/H+ antiporter NhaA	-
FEM44_RS14605	2990105..2991010	+	906	WP_135486694.1	transcriptional activator NhaR	-
FEM44_RS14610	2991102..2991365	-	264	WP_001274019.1	30S ribosomal protein S20	-
FEM44_RS14615	2991468..2991686	+	219	WP_064525381.1	DUF2575 family protein	-
FEM44_RS14620	2991694..2992635	+	942	WP_135523744.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T125814 WP_000935262.1 NZ_CP040443:c2988351-2988142 [Escherichia sp. E4742]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T125814 NZ_CP040443:c2988351-2988142 [Escherichia sp. E4742]
ATGCTGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT125814 NZ_CP040443:2988343-2988400 [Escherichia sp. E4742]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin