Detailed information of TA system TA125810

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 1824339..1825657
• Replicon: chromosome
• Accession: NZ_CP040443
• Organism: Escherichia sp. E4742

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: FEM44_RS08860
• Protein ID: WP_135522587.1
• Coordinates: 1824339..1825346 (-)
• Length: 336 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: -
• Locus tag: FEM44_RS08865
• Protein ID: WP_130210092.1
• Coordinates: 1825346..1825657 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEM44_RS08820	1819550..1819741	+	192	WP_130216286.1	cellulose biosynthesis protein BcsF	-
FEM44_RS08825	1819738..1821417	+	1680	WP_138158978.1	cellulose biosynthesis protein BcsG	-
FEM44_RS08830	1821503..1821610	-	108	WP_002431793.1	type I toxin-antitoxin system toxin Ldr family protein	-
FEM44_RS08835	1821985..1822092	-	108	WP_074399497.1	type I toxin-antitoxin system toxin Ldr family protein	-
FEM44_RS08845	1822468..1822575	-	108	WP_002431793.1	type I toxin-antitoxin system toxin Ldr family protein	-
FEM44_RS08850	1822647..1822820	+	174	WP_171022592.1	hypothetical protein	-
FEM44_RS08855	1823051..1824322	+	1272	WP_130210096.1	amino acid permease	-
FEM44_RS08860	1824339..1825346	-	1008	WP_135522587.1	HipA domain-containing protein	Toxin
FEM44_RS08865	1825346..1825657	-	312	WP_130210092.1	HipA N-terminal domain-containing protein	Antitoxin
FEM44_RS08870	1825642..1825965	-	324	WP_130222989.1	helix-turn-helix transcriptional regulator	-
FEM44_RS08875	1826190..1827203	-	1014	WP_135522586.1	dipeptide ABC transporter ATP-binding subunit DppF	-
FEM44_RS08880	1827200..1828183	-	984	WP_135522585.1	dipeptide ABC transporter ATP-binding protein	-
FEM44_RS08885	1828194..1829096	-	903	WP_135522584.1	dipeptide ABC transporter permease DppC	-
FEM44_RS08890	1829106..1830125	-	1020	WP_000938857.1	dipeptide ABC transporter permease DppB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-302)

Antitoxin

• HipA, N-terminal subdomain 1 (6-98)

Sequences

Toxin

Protein

• Length: 336 a.a.
• Molecular weight: 38343.59 Da
• Isoelectric Point: 5.4223

>T125810 WP_135522587.1 NZ_CP040443:c1825346-1824339 [Escherichia sp. E4742]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTTKLNPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDDKGQPVHQEQLDGAMQITD
KYGKTGNDNEQYVSYETLARFLIAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLMREEGGRELAPGFDSGYGEYIGQDFLLLGESMGLAPRLLEKIFQDIRKENSIVMETYEQSFMTQEH
IQAVLKCYRHRLGLL

Nucleotide

• Length: 1008 bp

>T125810 NZ_CP040443:c1825346-1824339 [Escherichia sp. E4742]
ATGGCGAATTGTCGCATTCTGTTAACGCCGCTGAATGAACGTGACGAACAGCGCGGATATTCGACACAGGGGTTGAAGCG
CCTGAGCGGCACTACAAAATTGAATCCTCGGCTGGGGTTTACGCGAACTCAGTTTGTGCAGGAACTTCCGCGTCAACAAA
AAGGGATGAGTATTTCCGGTTACCAGCCCAAGTTGCAATTAGTGCTGGATGAAGGAGAGTTCCGCGTCGTAGATCATCAG
GGAAATTTTATCCTTAAGCCCTCTCCAGCCGACTTTCCCGGTTTGGCCGAAAATGAACACGCAACAATGACATTAATGTC
TCGTTTGGGATTTGACGTACCTGTGCATGGCCTGCTGAGTTTTGCACCACAATCAGAGGAGGAGCTTGAATACGCGTTTG
TTATCCGGCGCTATGACCGGGATGACAAGGGGCAGCCAGTGCATCAGGAGCAACTTGATGGCGCGATGCAGATTACAGAT
AAATATGGCAAAACGGGAAATGATAACGAGCAATACGTCAGCTATGAAACGCTGGCCCGATTTTTAATTGCCCATGTTAA
CGACAACATCGCATTTAAAATCGATCTCTTTCGTCGCATTGTTTACGCCTGGTTGCTGGGTAATAACGACATGCATTTAC
GAAACTTTGGCTTAGTGTACTCCGATGGTTTGACGCCAGCGTTAGCGCCGGTGTATGACTTTGTTTCTGTCGCTCCCTAT
CCGGAATATTTTCACTCAAACTATCTGGCGCTGCCGTTATTGATGCGAGAAGAAGGCGGCCGGGAACTGGCTCCTGGATT
TGACAGTGGTTATGGCGAGTATATCGGGCAGGACTTTTTGCTGTTGGGTGAATCGATGGGATTAGCGCCCAGATTGCTGG
AAAAAATCTTTCAGGATATACGTAAAGAAAATTCCATTGTTATGGAAACGTATGAACAGTCCTTTATGACTCAGGAGCAT
ATCCAGGCTGTACTGAAATGCTATCGACATCGTCTGGGGCTGCTGTGA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11775.34 Da
• Isoelectric Point: 6.0609

>AT125810 WP_130210092.1 NZ_CP040443:c1825657-1825346 [Escherichia sp. E4742]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSETLHPYFASLAPEGWLRQRYSQIQHRDEND
PLGMLIDNGKNLLGAIQILPWEE

Nucleotide

• Length: 312 bp

>AT125810 NZ_CP040443:c1825657-1825346 [Escherichia sp. E4742]
ATGCATCGACGAGTGAAAGTGTTGCTCTATGGTCAGGTAGTGGGTGAACTCTCTCAGAACGACAGTGGTTTTTTGTTCCA
GTACGCCCCGGATTACCACGGACCGGCAATCTCAATCAGTCTGCCCGTCGCACAGCGTCAGTTTCCCAGTGAGACGTTGC
ATCCTTATTTTGCCTCACTGGCGCCAGAAGGATGGCTGCGTCAACGCTACAGCCAGATACAGCATCGTGACGAAAACGAT
CCGCTGGGAATGCTTATTGATAACGGCAAGAATCTGCTGGGGGCAATCCAAATTTTACCTTGGGAGGAATAA