Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3855819..3856407 Replicon chromosome
Accession NZ_CP040437
Organism Stenotrophomonas maltophilia strain PEG-305

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FEO90_RS17500 Protein ID WP_080355515.1
Coordinates 3856129..3856407 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8E3RGU6
Locus tag FEO90_RS17495 Protein ID WP_049439995.1
Coordinates 3855819..3856118 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEO90_RS17475 3851232..3852419 + 1188 WP_154331215.1 pyridoxal phosphate-dependent aminotransferase -
FEO90_RS17480 3852544..3854640 - 2097 WP_049464633.1 prolyl oligopeptidase family protein -
FEO90_RS17485 3854710..3855033 - 324 WP_154331216.1 hypothetical protein -
FEO90_RS17490 3855162..3855764 + 603 WP_049464637.1 lipocalin family protein -
FEO90_RS17495 3855819..3856118 - 300 WP_049439995.1 HigA family addiction module antidote protein Antitoxin
FEO90_RS17500 3856129..3856407 - 279 WP_080355515.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FEO90_RS17505 3856614..3857303 - 690 WP_150827059.1 ABC transporter permease -
FEO90_RS17510 3857300..3858307 - 1008 WP_010481369.1 methionine ABC transporter ATP-binding protein -
FEO90_RS17515 3858518..3859414 - 897 WP_014038546.1 DMT family transporter -
FEO90_RS17520 3859510..3859992 + 483 WP_049464641.1 YajQ family cyclic di-GMP-binding protein -
FEO90_RS17525 3860027..3861124 - 1098 WP_154331217.1 Fis family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(27-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10682.19 Da        Isoelectric Point: 10.4115

>T125800 WP_080355515.1 NZ_CP040437:c3856407-3856129 [Stenotrophomonas maltophilia]
MIRSFRCKQTRALFEGACPRAWRPIRRAAERKLQLLDSAQTLAFLRSPPGNRLEALSGDRRGQYSLRINDQWRLCFTWTD
SGADAVEIVDYH

Download         Length: 279 bp

>T125800 NZ_CP040437:c3856407-3856129 [Stenotrophomonas maltophilia]
ATGATCCGTTCATTCCGCTGCAAGCAGACCCGCGCCCTGTTTGAAGGAGCCTGCCCTCGCGCTTGGCGCCCGATACGACG
CGCGGCTGAACGTAAACTCCAGCTGCTCGATTCGGCACAGACGCTGGCCTTCCTGCGCAGCCCGCCCGGGAATCGTCTTG
AGGCGCTGTCAGGTGATCGGAGAGGACAATACAGCCTCCGTATCAACGATCAGTGGCGGCTCTGTTTCACCTGGACCGAC
AGCGGCGCCGATGCCGTGGAAATTGTTGACTATCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10885.59 Da        Isoelectric Point: 11.3450

>AT125800 WP_049439995.1 NZ_CP040437:c3856118-3855819 [Stenotrophomonas maltophilia]
MKRPHNGMRAIHPGEILREEFLLPLSLSVNALAKALDVPATRLHAIVHGQRSISADTAARLARHFGGDAASWLAMQAAYD
LKTLPTRSEIERRVQPRAA

Download         Length: 300 bp

>AT125800 NZ_CP040437:c3856118-3855819 [Stenotrophomonas maltophilia]
ATGAAGCGTCCCCACAACGGCATGCGCGCCATCCATCCTGGCGAGATCCTGCGCGAAGAGTTTCTGCTGCCCCTGTCGCT
GAGCGTGAATGCGCTGGCGAAGGCGCTGGATGTTCCCGCAACGCGGCTGCACGCCATCGTCCACGGTCAGCGCAGCATCT
CGGCGGACACGGCAGCGCGGTTGGCACGGCATTTCGGCGGGGATGCCGCTTCCTGGCTTGCGATGCAGGCGGCCTACGAT
CTCAAGACATTGCCAACACGCAGCGAGATCGAACGCCGCGTACAGCCTCGGGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References