Detailed information of TA system TA125796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1802695..1803197
• Replicon: chromosome
• Accession: NZ_CP040432
• Organism: Stenotrophomonas maltophilia strain sm-RA9

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: M5CW48
• Locus tag: FEO95_RS08250
• Protein ID: WP_004152371.1
• Coordinates: 1802943..1803197 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: M5D711
• Locus tag: FEO95_RS08245
• Protein ID: WP_004152370.1
• Coordinates: 1802695..1802946 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEO95_RS08215	1798313..1799041	+	729	WP_004152366.1	ABC transporter ATP-binding protein	-
FEO95_RS08220	1799038..1799952	+	915	WP_004152367.1	HlyD family efflux transporter periplasmic adaptor subunit	-
FEO95_RS08225	1799955..1800404	-	450	WP_004152368.1	hypothetical protein	-
FEO95_RS08230	1800397..1800798	-	402	WP_012510622.1	hypothetical protein	-
FEO95_RS08240	1801228..1802598	+	1371	WP_004152369.1	tyrosine-type recombinase/integrase	-
FEO95_RS08245	1802695..1802946	+	252	WP_004152370.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
FEO95_RS08250	1802943..1803197	+	255	WP_004152371.1	Txe/YoeB family addiction module toxin	Toxin
FEO95_RS08255	1803412..1803801	+	390	WP_004152373.1	DUF3742 family protein	-
FEO95_RS08260	1803809..1805329	-	1521	WP_004152375.1	conjugal transfer protein TraG N-terminal domain-containing protein	-
FEO95_RS08265	1805344..1805694	-	351	WP_004152376.1	hypothetical protein	-
FEO95_RS08270	1806055..1806291	+	237	WP_050559875.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10156.63 Da
• Isoelectric Point: 9.4089

>T125796 WP_004152371.1 NZ_CP040432:1802943-1803197 [Stenotrophomonas maltophilia]
VKLIWSEQAWDDYLYWQDADKRMVKKINELIKETRRTPFEGKGKPEPLRHNLAGFWSRRITAEHRFVYSVTDEALLIAAC
RYHY

Nucleotide

• Length: 255 bp

>T125796 NZ_CP040432:1802943-1803197 [Stenotrophomonas maltophilia]
GTGAAGCTGATCTGGTCTGAGCAAGCCTGGGATGATTATCTGTATTGGCAGGACGCAGATAAGCGTATGGTCAAGAAGAT
CAACGAGCTGATCAAGGAGACCCGTCGCACCCCTTTCGAGGGCAAGGGCAAACCGGAGCCGCTGCGCCACAACTTGGCGG
GGTTCTGGTCGAGGCGGATCACCGCCGAGCACCGGTTTGTGTATTCGGTGACGGATGAGGCGCTGTTGATTGCCGCCTGC
CGTTATCACTATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9362.57 Da
• Isoelectric Point: 4.7707

>AT125796 WP_004152370.1 NZ_CP040432:1802695-1802946 [Stenotrophomonas maltophilia]
MRTISYTEARQNLSATMVQTVEDRAPTLITRQNGEACVLMSLEEYNALEETAYLLRSPANARRLMDSIDSLKRGQGVERN
IAE

Nucleotide

• Length: 252 bp

>AT125796 NZ_CP040432:1802695-1802946 [Stenotrophomonas maltophilia]
ATGCGCACTATCAGCTATACCGAAGCCCGGCAGAACCTGTCGGCCACCATGGTGCAGACCGTCGAGGATCGCGCCCCGAC
CCTGATAACCCGCCAGAACGGTGAGGCGTGCGTGCTGATGTCGCTGGAGGAGTACAACGCGCTGGAGGAAACGGCTTACC
TGCTGCGCTCTCCGGCCAACGCACGCCGCCTGATGGATTCGATTGACAGCCTCAAGCGAGGTCAGGGTGTCGAGCGGAAT
ATCGCCGAGTGA

Structures

Toxin

• AlphaFold DB: M5CW48

Antitoxin

• AlphaFold DB: M5D711