Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1231368..1231964 Replicon chromosome
Accession NZ_CP040349
Organism Pseudomonas guguanensis strain HMFL31

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FE254_RS05465 Protein ID WP_090426965.1
Coordinates 1231686..1231964 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FE254_RS05460 Protein ID WP_079784482.1
Coordinates 1231368..1231673 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE254_RS05425 (FE254_05475) 1226499..1228415 + 1917 WP_286586505.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
FE254_RS05430 (FE254_05480) 1228709..1229623 + 915 WP_286586507.1 DMT family transporter -
FE254_RS05435 (FE254_05485) 1229778..1230224 - 447 WP_286586508.1 hypothetical protein -
FE254_RS05440 1230250..1230414 - 165 WP_090427008.1 hypothetical protein -
FE254_RS05445 (FE254_05490) 1230520..1230729 - 210 WP_139205530.1 hypothetical protein -
FE254_RS05455 (FE254_05500) 1231106..1231276 - 171 WP_286586511.1 YhfG family protein -
FE254_RS05460 (FE254_05505) 1231368..1231673 - 306 WP_079784482.1 HigA family addiction module antitoxin Antitoxin
FE254_RS05465 (FE254_05510) 1231686..1231964 - 279 WP_090426965.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FE254_RS05470 (FE254_05515) 1232072..1232572 - 501 WP_286586517.1 BRO family protein -
FE254_RS05475 (FE254_05525) 1233148..1234662 + 1515 WP_057391508.1 IS21 family transposase -
FE254_RS05480 (FE254_05530) 1234680..1235435 + 756 WP_132667926.1 IS21-like element helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10554.01 Da        Isoelectric Point: 8.5556

>T125573 WP_090426965.1 NZ_CP040349:c1231964-1231686 [Pseudomonas guguanensis]
MILSFRCAETQALFESGSSRRWANILNVATRKLTMLNAAVELRDLRSPPGNRLEQLQGNRADQHSIRINDQWRICFVWTA
AGPTQVEIVDYH

Download         Length: 279 bp

>T125573 NZ_CP040349:c1231964-1231686 [Pseudomonas guguanensis]
ATGATCCTGAGTTTCAGATGCGCAGAAACCCAGGCTCTGTTTGAGTCAGGAAGCTCCAGACGCTGGGCCAACATTCTCAA
TGTGGCCACGCGGAAGCTGACGATGCTGAATGCAGCCGTTGAGCTGCGCGACCTCCGCTCTCCACCAGGCAACCGGCTGG
AGCAGCTACAAGGCAATCGAGCAGATCAACACAGCATCAGAATCAACGATCAATGGCGAATCTGCTTTGTGTGGACTGCC
GCTGGTCCTACACAAGTCGAGATCGTCGACTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11055.62 Da        Isoelectric Point: 4.7616

>AT125573 WP_079784482.1 NZ_CP040349:c1231673-1231368 [Pseudomonas guguanensis]
MAINGMRPVHPGEVLREEFLEPLGMTPAALARALHVSAPTINDIVRERRGITADTAIRLGRYFDTSAQFWMNLQTEYALA
ATYAESGAAIEQAIEPLQIAS

Download         Length: 306 bp

>AT125573 NZ_CP040349:c1231673-1231368 [Pseudomonas guguanensis]
ATGGCTATCAACGGCATGCGCCCCGTTCACCCTGGCGAAGTGCTACGCGAAGAGTTTCTTGAGCCGCTGGGCATGACCCC
AGCCGCACTTGCTCGCGCTCTGCATGTGTCGGCGCCGACCATCAATGACATCGTACGGGAGCGTCGTGGCATTACCGCCG
ATACGGCTATTCGTCTAGGCCGCTACTTCGACACCTCAGCTCAGTTCTGGATGAACTTGCAGACTGAGTATGCACTGGCG
GCAACTTACGCCGAGTCTGGCGCAGCCATCGAGCAGGCCATTGAGCCGCTTCAGATAGCGAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References