Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4937037..4937830 Replicon chromosome
Accession NZ_CP040324
Organism Pseudomonas monteilii strain TCU-CK1

Toxin (Protein)


Gene name yhaV Uniprot ID A0A1W2CLZ8
Locus tag TCK1_RS22495 Protein ID WP_019098849.1
Coordinates 4937360..4937830 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A1W2CMY6
Locus tag TCK1_RS22490 Protein ID WP_019098850.1
Coordinates 4937037..4937363 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TCK1_RS22470 4932634..4933695 - 1062 WP_019098854.1 HlyD family secretion protein -
TCK1_RS22475 4933724..4935265 - 1542 WP_019098853.1 MFS transporter -
TCK1_RS22480 4935382..4936288 - 907 Protein_4420 LysR family transcriptional regulator -
TCK1_RS22485 4936497..4936943 + 447 WP_084297082.1 universal stress protein -
TCK1_RS22490 4937037..4937363 + 327 WP_019098850.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
TCK1_RS22495 4937360..4937830 + 471 WP_019098849.1 type II toxin-antitoxin system YhaV family toxin Toxin
TCK1_RS22500 4937838..4938698 - 861 WP_016713502.1 HlyD family secretion protein -
TCK1_RS22505 4938709..4938909 - 201 WP_009685040.1 DUF1656 domain-containing protein -
TCK1_RS22510 4938899..4941076 - 2178 WP_019098848.1 FUSC family protein -
TCK1_RS22515 4941073..4942602 - 1530 WP_019098847.1 efflux transporter outer membrane subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(16-152)

Antitoxin

PrlF antitoxin

(8-106)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 18235.65 Da        Isoelectric Point: 9.7367

>T125562 WP_019098849.1 NZ_CP040324:4937360-4937830 [Pseudomonas monteilii]
MSDASRKPLVIHGWTVFAHPLFLAKLEALSTQVHAQMQKDPTGYTERNAYKRLAAIKRLAFDVIPQDPTKSEYRQGATLG
EGHKHWFRAKFFQQYRLFFRYHTPSRIIVLAWVNDESSKRAYESHDDAYKVFQKMLDNGNPPDDWDQLLREAAQQP

Download         Length: 471 bp

>T125562 NZ_CP040324:4937360-4937830 [Pseudomonas monteilii]
ATGAGTGATGCGAGCAGGAAGCCTCTGGTTATTCATGGATGGACTGTATTTGCCCACCCGCTGTTCCTGGCCAAACTGGA
GGCACTGAGCACTCAAGTTCATGCTCAGATGCAGAAAGACCCAACAGGTTACACGGAAAGAAATGCCTATAAGCGGCTGG
CGGCTATCAAGCGTTTGGCTTTTGATGTGATCCCTCAGGACCCGACCAAATCTGAATACCGCCAAGGCGCCACGCTGGGC
GAGGGTCACAAGCACTGGTTTCGGGCAAAGTTCTTTCAGCAGTACCGGTTGTTCTTTCGCTACCACACCCCCAGCAGGAT
CATCGTGCTGGCCTGGGTCAATGACGAATCAAGCAAGCGGGCTTATGAAAGTCATGACGATGCTTACAAGGTCTTCCAGA
AAATGCTCGACAACGGCAACCCTCCCGATGATTGGGATCAGTTGCTGAGGGAAGCCGCACAGCAACCGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12017.49 Da        Isoelectric Point: 4.3118

>AT125562 WP_019098850.1 NZ_CP040324:4937037-4937363 [Pseudomonas monteilii]
MATTLDVESTLTDRYQTTVPETVRRALGLKKRDKIHYSIRPDGEVILTRAEATESDPVLGKFLDFLAHDIATNPQRLQVV
DADLIARLDKLVGDAEVDLDQPLSADDE

Download         Length: 327 bp

>AT125562 NZ_CP040324:4937037-4937363 [Pseudomonas monteilii]
ATGGCAACCACTCTCGACGTCGAGTCCACACTGACCGATCGCTATCAGACCACTGTTCCCGAAACAGTACGGCGCGCCTT
GGGCTTGAAAAAACGTGACAAGATCCATTACTCGATTCGCCCTGACGGTGAGGTGATACTCACCCGTGCAGAAGCAACCG
AGAGCGATCCGGTACTGGGCAAATTTCTGGATTTCCTGGCACACGATATCGCCACCAACCCTCAACGGCTGCAGGTTGTC
GATGCTGACCTCATCGCGCGTCTCGACAAGCTTGTCGGCGACGCAGAGGTCGACCTGGATCAACCTCTGTCGGCGGATGA
TGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W2CLZ8

Antitoxin

Source ID Structure
AlphaFold DB A0A1W2CMY6

References