Detailed information of TA system TA125513

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 5183954..5184175
• Replicon: chromosome
• Accession: NZ_CP040314
• Organism: Escherichia coli strain MA11

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: FEL10_RS25630
• Protein ID: WP_001295224.1
• Coordinates: 5183954..5184061 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	5184110..5184175 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEL10_RS25605	5179207..5179959	-	753	Protein_4983	cellulose biosynthesis protein BcsQ	-
FEL10_RS25610	5179971..5180159	-	189	WP_001063316.1	YhjR family protein	-
FEL10_RS25615	5180432..5182003	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
FEL10_RS25620	5182000..5182191	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
FEL10_RS25625	5182188..5183867	+	1680	WP_000191592.1	cellulose biosynthesis protein BcsG	-
FEL10_RS25630	5183954..5184061	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	5184110..5184175	+	66	NuclAT_16	-	Antitoxin
-	5184110..5184175	+	66	NuclAT_16	-	Antitoxin
-	5184110..5184175	+	66	NuclAT_16	-	Antitoxin
-	5184110..5184175	+	66	NuclAT_16	-	Antitoxin
-	5184110..5184175	+	66	NuclAT_21	-	Antitoxin
-	5184110..5184175	+	66	NuclAT_21	-	Antitoxin
-	5184110..5184175	+	66	NuclAT_21	-	Antitoxin
-	5184110..5184175	+	66	NuclAT_21	-	Antitoxin
FEL10_RS25635	5184537..5185808	+	1272	WP_001301684.1	amino acid permease	-
FEL10_RS25640	5185838..5186842	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
FEL10_RS25645	5186839..5187822	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
FEL10_RS25650	5187833..5188735	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T125513 WP_001295224.1 NZ_CP040314:c5184061-5183954 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T125513 NZ_CP040314:c5184061-5183954 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT125513 NZ_CP040314:5184110-5184175 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin