Detailed information of TA system TA125494

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2881175..2881400
• Replicon: chromosome
• Accession: NZ_CP040314
• Organism: Escherichia coli strain MA11

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: FEL10_RS14015
• Protein ID: WP_000967408.1
• Coordinates: 2881175..2881387 (-)
• Length: 71 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2881342..2881400 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEL10_RS13985	2876478..2877536	-	1059	WP_000483497.1	site-specific DNA-methyltransferase	-
FEL10_RS13990	2877687..2877884	-	198	WP_000917735.1	hypothetical protein	-
FEL10_RS13995	2878111..2878932	-	822	WP_000762904.1	antitermination protein	-
FEL10_RS14000	2878929..2879303	-	375	WP_000904137.1	RusA family crossover junction endodeoxyribonuclease	-
FEL10_RS14005	2879316..2880365	-	1050	Protein_2727	DUF968 domain-containing protein	-
FEL10_RS14010	2880367..2880645	-	279	WP_001304183.1	hypothetical protein	-
FEL10_RS27575	2880711..2880878	-	168	WP_000998188.1	hypothetical protein	-
FEL10_RS14015	2881175..2881387	-	213	WP_000967408.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	2881342..2881400	+	59	-	-	Antitoxin
FEL10_RS14020	2881576..2881680	-	105	WP_001278450.1	hypothetical protein	-
FEL10_RS14025	2881796..2882158	-	363	WP_000610379.1	DUF551 domain-containing protein	-
FEL10_RS14030	2882155..2882526	-	372	WP_000137941.1	hypothetical protein	-
FEL10_RS14035	2882562..2882774	-	213	WP_000063625.1	hypothetical protein	-
FEL10_RS14040	2882823..2883179	-	357	WP_001302146.1	hypothetical protein	-
FEL10_RS14045	2883236..2883631	-	396	WP_001118161.1	DUF977 family protein	-
FEL10_RS14050	2883647..2884417	-	771	WP_000450888.1	DUF1627 domain-containing protein	-
FEL10_RS14055	2884447..2885187	-	741	WP_000790456.1	ATP-binding protein	-
FEL10_RS14060	2885194..2886147	-	954	WP_000095667.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleC	2849094..2939506	90412

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7958.54 Da
• Isoelectric Point: 9.6297

>T125494 WP_000967408.1 NZ_CP040314:c2881387-2881175 [Escherichia coli]
MLYTRRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 213 bp

>T125494 NZ_CP040314:c2881387-2881175 [Escherichia coli]
ATGCTCTACACACGTAGGTTAGCCTCTTACGTGCCGAAAGGCAAGGAGAAGCAGGCTATGAAGCAGCAAAAGGCGATGCT
AATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAAAGACCTCTGCGAGGTACGAATCC
GAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT125494 NZ_CP040314:2881342-2881400 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Structures

Antitoxin