Detailed information of TA system TA125491

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2516948..2517173
• Replicon: chromosome
• Accession: NZ_CP040314
• Organism: Escherichia coli strain MA11

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: FEL10_RS12290
• Protein ID: WP_000935259.1
• Coordinates: 2516961..2517173 (+)
• Length: 71 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2516948..2517006 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEL10_RS12240	2512013..2512255	+	243	WP_000747948.1	hypothetical protein	-
FEL10_RS12245	2512239..2512664	+	426	WP_000693878.1	Rha family transcriptional regulator	-
FEL10_RS12250	2512733..2513776	+	1044	WP_001262402.1	hypothetical protein	-
FEL10_RS12255	2513769..2514230	+	462	WP_000139447.1	replication protein	-
FEL10_RS12260	2514264..2514980	+	717	WP_000450627.1	DUF1627 domain-containing protein	-
FEL10_RS12265	2515013..2515294	+	282	WP_000603384.1	DNA-binding protein	-
FEL10_RS12270	2515291..2515518	+	228	WP_000699809.1	hypothetical protein	-
FEL10_RS12275	2515511..2515822	+	312	WP_001289673.1	hypothetical protein	-
FEL10_RS12280	2515950..2516168	+	219	WP_000683609.1	DUF4014 family protein	-
FEL10_RS12285	2516170..2516727	+	558	WP_000104474.1	DUF551 domain-containing protein	-
-	2516948..2517006	-	59	-	-	Antitoxin
FEL10_RS12290	2516961..2517173	+	213	WP_000935259.1	type I toxin-antitoxin system Hok family toxin	Toxin
FEL10_RS12295	2517293..2517637	+	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
FEL10_RS12300	2517759..2518031	+	273	WP_000191872.1	hypothetical protein	-
FEL10_RS12305	2518033..2519082	+	1050	WP_001265229.1	DUF968 domain-containing protein	-
FEL10_RS12310	2519095..2519400	+	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
FEL10_RS12315	2519463..2520017	+	555	WP_000640035.1	DUF1133 family protein	-
FEL10_RS12320	2520242..2520439	+	198	WP_000917763.1	hypothetical protein	-
FEL10_RS12325	2520575..2521288	+	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
FEL10_RS12340	2521739..2522170	+	432	WP_001302123.1	tellurite resistance protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	paa / nleG7'	2453339..2554278	100939

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7887.47 Da
• Isoelectric Point: 9.2654

>T125491 WP_000935259.1 NZ_CP040314:2516961-2517173 [Escherichia coli]
MLNTCRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 213 bp

>T125491 NZ_CP040314:2516961-2517173 [Escherichia coli]
ATGCTGAACACATGTAGGTTAGCCTCTTACGTGCCGAAAGGCAAGGAGAAGCAGGCTATGAAGCAGCAAAAGGCGATGTT
AATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAAAGACCTCTGCGAGGTGCGAATCC
GAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT125491 NZ_CP040314:c2517006-2516948 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Antitoxin