Detailed information of TA system TA125486

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1964995..1965220
• Replicon: chromosome
• Accession: NZ_CP040314
• Organism: Escherichia coli strain MA11

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: FEL10_RS09140
• Protein ID: WP_000813263.1
• Coordinates: 1965065..1965220 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1964995..1965053 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEL10_RS09110	1960270..1961361	+	1092	WP_001205823.1	hypothetical protein	-
FEL10_RS09115	1961368..1962114	+	747	WP_000788751.1	ATP-binding protein	-
FEL10_RS09120	1962136..1962906	+	771	WP_000450992.1	DUF1627 domain-containing protein	-
FEL10_RS09125	1962922..1963335	+	414	WP_001151233.1	DUF977 family protein	-
FEL10_RS09130	1963687..1964460	-	774	WP_000160654.1	alpha/beta hydrolase	-
-	1964995..1965053	-	59	-	-	Antitoxin
FEL10_RS09140	1965065..1965220	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
FEL10_RS09145	1965388..1965666	+	279	WP_001341388.1	hypothetical protein	-
FEL10_RS09150	1965668..1966717	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
FEL10_RS09155	1966730..1967101	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
FEL10_RS09160	1967091..1967462	+	372	WP_000090264.1	antitermination protein	-
FEL10_RS09165	1967614..1968432	+	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
FEL10_RS09170	1968719..1968915	+	197	Protein_1783	TrmB family transcriptional regulator	-
FEL10_RS09175	1969053..1969766	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T125486 WP_000813263.1 NZ_CP040314:1965065-1965220 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T125486 NZ_CP040314:1965065-1965220 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT125486 NZ_CP040314:c1965053-1964995 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin