Detailed information of TA system TA125453

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2867595..2867820
• Replicon: chromosome
• Accession: NZ_CP040313
• Organism: Escherichia coli strain M7638

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: FEL02_RS13955
• Protein ID: WP_000935259.1
• Coordinates: 2867595..2867807 (-)
• Length: 71 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2867762..2867820 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEL02_RS13905	2862598..2863029	-	432	WP_001302123.1	tellurite resistance protein	-
FEL02_RS13920	2863480..2864193	-	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
FEL02_RS13925	2864329..2864526	-	198	WP_000917763.1	hypothetical protein	-
FEL02_RS13930	2864751..2865305	-	555	WP_000640035.1	DUF1133 family protein	-
FEL02_RS13935	2865368..2865673	-	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
FEL02_RS13940	2865686..2866735	-	1050	WP_001265229.1	DUF968 domain-containing protein	-
FEL02_RS13945	2866737..2867009	-	273	WP_000191872.1	hypothetical protein	-
FEL02_RS13950	2867131..2867475	-	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
FEL02_RS13955	2867595..2867807	-	213	WP_000935259.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	2867762..2867820	+	59	-	-	Antitoxin
FEL02_RS13960	2868041..2868598	-	558	WP_000104474.1	DUF551 domain-containing protein	-
FEL02_RS13965	2868600..2868818	-	219	WP_000683609.1	DUF4014 family protein	-
FEL02_RS13970	2868946..2869257	-	312	WP_001289673.1	hypothetical protein	-
FEL02_RS13975	2869250..2869477	-	228	WP_000699809.1	hypothetical protein	-
FEL02_RS13980	2869474..2869755	-	282	WP_000603384.1	DNA-binding protein	-
FEL02_RS13985	2869788..2870504	-	717	WP_000450627.1	DUF1627 domain-containing protein	-
FEL02_RS13990	2870538..2870999	-	462	WP_000139447.1	replication protein	-
FEL02_RS13995	2870992..2872035	-	1044	WP_001262402.1	hypothetical protein	-
FEL02_RS14000	2872104..2872529	-	426	WP_000693878.1	Rha family transcriptional regulator	-
FEL02_RS14005	2872513..2872755	-	243	WP_000747948.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	espM1 / nleA/espI	2830493..2947405	116912

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7887.47 Da
• Isoelectric Point: 9.2654

>T125453 WP_000935259.1 NZ_CP040313:c2867807-2867595 [Escherichia coli]
MLNTCRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 213 bp

>T125453 NZ_CP040313:c2867807-2867595 [Escherichia coli]
ATGCTGAACACATGTAGGTTAGCCTCTTACGTGCCGAAAGGCAAGGAGAAGCAGGCTATGAAGCAGCAAAAGGCGATGTT
AATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAAAGACCTCTGCGAGGTGCGAATCC
GAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT125453 NZ_CP040313:2867762-2867820 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Antitoxin