Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 2446300..2446514 Replicon chromosome
Accession NZ_CP040313
Organism Escherichia coli strain M7638

Toxin (Protein)


Gene name ldrD Uniprot ID J7R083
Locus tag FEL02_RS11880 Protein ID WP_000170963.1
Coordinates 2446300..2446407 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 2446455..2446514 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEL02_RS11850 2441609..2442691 + 1083 WP_000804726.1 peptide chain release factor 1 -
FEL02_RS11855 2442691..2443524 + 834 WP_000456466.1 peptide chain release factor N(5)-glutamine methyltransferase -
FEL02_RS11860 2443521..2443913 + 393 WP_000200379.1 invasion regulator SirB2 -
FEL02_RS11865 2443917..2444726 + 810 WP_001257044.1 invasion regulator SirB1 -
FEL02_RS11870 2444762..2445616 + 855 WP_000811067.1 3-deoxy-8-phosphooctulonate synthase -
FEL02_RS11875 2445764..2445871 - 108 WP_000170954.1 type I toxin-antitoxin system toxin Ldr family protein -
- 2445924..2445985 + 62 NuclAT_24 - -
- 2445924..2445985 + 62 NuclAT_24 - -
- 2445924..2445985 + 62 NuclAT_24 - -
- 2445924..2445985 + 62 NuclAT_24 - -
- 2445924..2445985 + 62 NuclAT_26 - -
- 2445924..2445985 + 62 NuclAT_26 - -
- 2445924..2445985 + 62 NuclAT_26 - -
- 2445924..2445985 + 62 NuclAT_26 - -
- 2445924..2445985 + 62 NuclAT_28 - -
- 2445924..2445985 + 62 NuclAT_28 - -
- 2445924..2445985 + 62 NuclAT_28 - -
- 2445924..2445985 + 62 NuclAT_28 - -
- 2445924..2445985 + 62 NuclAT_30 - -
- 2445924..2445985 + 62 NuclAT_30 - -
- 2445924..2445985 + 62 NuclAT_30 - -
- 2445924..2445985 + 62 NuclAT_30 - -
- 2445924..2445985 + 62 NuclAT_32 - -
- 2445924..2445985 + 62 NuclAT_32 - -
- 2445924..2445985 + 62 NuclAT_32 - -
- 2445924..2445985 + 62 NuclAT_32 - -
- 2445924..2445986 + 63 NuclAT_17 - -
- 2445924..2445986 + 63 NuclAT_17 - -
- 2445924..2445986 + 63 NuclAT_17 - -
- 2445924..2445986 + 63 NuclAT_17 - -
- 2445924..2445986 + 63 NuclAT_18 - -
- 2445924..2445986 + 63 NuclAT_18 - -
- 2445924..2445986 + 63 NuclAT_18 - -
- 2445924..2445986 + 63 NuclAT_18 - -
- 2445924..2445986 + 63 NuclAT_19 - -
- 2445924..2445986 + 63 NuclAT_19 - -
- 2445924..2445986 + 63 NuclAT_19 - -
- 2445924..2445986 + 63 NuclAT_19 - -
- 2445924..2445986 + 63 NuclAT_20 - -
- 2445924..2445986 + 63 NuclAT_20 - -
- 2445924..2445986 + 63 NuclAT_20 - -
- 2445924..2445986 + 63 NuclAT_20 - -
- 2445924..2445986 + 63 NuclAT_22 - -
- 2445924..2445986 + 63 NuclAT_22 - -
- 2445924..2445986 + 63 NuclAT_22 - -
- 2445924..2445986 + 63 NuclAT_22 - -
- 2445924..2445986 + 63 NuclAT_23 - -
- 2445924..2445986 + 63 NuclAT_23 - -
- 2445924..2445986 + 63 NuclAT_23 - -
- 2445924..2445986 + 63 NuclAT_23 - -
FEL02_RS11880 2446300..2446407 - 108 WP_000170963.1 small toxic polypeptide LdrB Toxin
- 2446455..2446514 + 60 NuclAT_25 - Antitoxin
- 2446455..2446514 + 60 NuclAT_25 - Antitoxin
- 2446455..2446514 + 60 NuclAT_25 - Antitoxin
- 2446455..2446514 + 60 NuclAT_25 - Antitoxin
- 2446455..2446514 + 60 NuclAT_27 - Antitoxin
- 2446455..2446514 + 60 NuclAT_27 - Antitoxin
- 2446455..2446514 + 60 NuclAT_27 - Antitoxin
- 2446455..2446514 + 60 NuclAT_27 - Antitoxin
- 2446455..2446514 + 60 NuclAT_29 - Antitoxin
- 2446455..2446514 + 60 NuclAT_29 - Antitoxin
- 2446455..2446514 + 60 NuclAT_29 - Antitoxin
- 2446455..2446514 + 60 NuclAT_29 - Antitoxin
- 2446455..2446514 + 60 NuclAT_31 - Antitoxin
- 2446455..2446514 + 60 NuclAT_31 - Antitoxin
- 2446455..2446514 + 60 NuclAT_31 - Antitoxin
- 2446455..2446514 + 60 NuclAT_31 - Antitoxin
- 2446455..2446514 + 60 NuclAT_33 - Antitoxin
- 2446455..2446514 + 60 NuclAT_33 - Antitoxin
- 2446455..2446514 + 60 NuclAT_33 - Antitoxin
- 2446455..2446514 + 60 NuclAT_33 - Antitoxin
FEL02_RS11885 2446806..2447906 - 1101 WP_001301956.1 sodium-potassium/proton antiporter ChaA -
FEL02_RS11890 2448176..2448406 + 231 WP_001146444.1 putative cation transport regulator ChaB -
FEL02_RS11895 2448567..2449262 + 696 WP_001301489.1 glutathione-specific gamma-glutamylcyclotransferase -
FEL02_RS11900 2449306..2449659 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -
FEL02_RS11905 2449845..2451239 + 1395 WP_000086192.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3971.74 Da        Isoelectric Point: 11.4779

>T125450 WP_000170963.1 NZ_CP040313:c2446407-2446300 [Escherichia coli]
MTLAQFAMTFWHDLAAPILAGIITAAIVGWWRNRK

Download         Length: 108 bp

>T125450 NZ_CP040313:c2446407-2446300 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 60 bp

>AT125450 NZ_CP040313:2446455-2446514 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References