Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 691766..692178 Replicon chromosome
Accession NZ_CP040313
Organism Escherichia coli strain M7638

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag FEL02_RS03165 Protein ID WP_000132630.1
Coordinates 691766..692107 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 692102..692178 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEL02_RS26600 687334..687534 + 201 WP_001310455.1 hypothetical protein -
FEL02_RS03145 687777..689189 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
FEL02_RS03150 689366..689530 + 165 WP_000394274.1 DUF1127 domain-containing protein -
FEL02_RS03155 689627..690508 + 882 WP_001304007.1 DUF262 domain-containing protein -
FEL02_RS03160 690556..691719 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
FEL02_RS03165 691766..692107 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- 692102..692178 + 77 NuclAT_14 - Antitoxin
- 692102..692178 + 77 NuclAT_14 - Antitoxin
- 692102..692178 + 77 NuclAT_14 - Antitoxin
- 692102..692178 + 77 NuclAT_14 - Antitoxin
- 692102..692178 + 77 NuclAT_15 - Antitoxin
- 692102..692178 + 77 NuclAT_15 - Antitoxin
- 692102..692178 + 77 NuclAT_15 - Antitoxin
- 692102..692178 + 77 NuclAT_15 - Antitoxin
FEL02_RS03170 692328..694082 - 1755 WP_000110082.1 restriction endonuclease subunit S -
FEL02_RS03175 694082..695551 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 681259..699979 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T125437 WP_000132630.1 NZ_CP040313:c692107-691766 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T125437 NZ_CP040313:c692107-691766 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT125437 NZ_CP040313:692102-692178 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References