Detailed information of TA system TA125431

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 5104787..5105008
• Replicon: chromosome
• Accession: NZ_CP040311
• Organism: Escherichia coli strain F3398

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: FEL04_RS24975
• Protein ID: WP_001295224.1
• Coordinates: 5104787..5104894 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	5104943..5105008 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEL04_RS24950	5100040..5100792	-	753	Protein_4853	cellulose biosynthesis protein BcsQ	-
FEL04_RS24955	5100804..5100992	-	189	WP_001063316.1	YhjR family protein	-
FEL04_RS24960	5101265..5102836	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
FEL04_RS24965	5102833..5103024	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
FEL04_RS24970	5103021..5104700	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
FEL04_RS24975	5104787..5104894	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	5104943..5105008	+	66	NuclAT_16	-	Antitoxin
-	5104943..5105008	+	66	NuclAT_16	-	Antitoxin
-	5104943..5105008	+	66	NuclAT_16	-	Antitoxin
-	5104943..5105008	+	66	NuclAT_16	-	Antitoxin
-	5104943..5105008	+	66	NuclAT_21	-	Antitoxin
-	5104943..5105008	+	66	NuclAT_21	-	Antitoxin
-	5104943..5105008	+	66	NuclAT_21	-	Antitoxin
-	5104943..5105008	+	66	NuclAT_21	-	Antitoxin
FEL04_RS24980	5105370..5106641	+	1272	WP_001301684.1	amino acid permease	-
FEL04_RS24985	5106671..5107675	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
FEL04_RS24990	5107672..5108655	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
FEL04_RS24995	5108666..5109568	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T125431 WP_001295224.1 NZ_CP040311:c5104894-5104787 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T125431 NZ_CP040311:c5104894-5104787 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT125431 NZ_CP040311:5104943-5105008 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin