Detailed information of TA system TA125412

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2852378..2852603
• Replicon: chromosome
• Accession: NZ_CP040311
• Organism: Escherichia coli strain F3398

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: FEL04_RS13645
• Protein ID: WP_000935259.1
• Coordinates: 2852378..2852590 (-)
• Length: 71 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2852545..2852603 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEL04_RS13595	2847381..2847812	-	432	WP_001302123.1	tellurite resistance protein	-
FEL04_RS13610	2848263..2848976	-	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
FEL04_RS13615	2849112..2849309	-	198	WP_000917763.1	hypothetical protein	-
FEL04_RS13620	2849534..2850088	-	555	WP_000640035.1	DUF1133 family protein	-
FEL04_RS13625	2850151..2850456	-	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
FEL04_RS13630	2850469..2851518	-	1050	WP_001265229.1	DUF968 domain-containing protein	-
FEL04_RS13635	2851520..2851792	-	273	WP_000191871.1	hypothetical protein	-
FEL04_RS13640	2851914..2852258	-	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
FEL04_RS13645	2852378..2852590	-	213	WP_000935259.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	2852545..2852603	+	59	-	-	Antitoxin
FEL04_RS13650	2852824..2853381	-	558	WP_000104474.1	DUF551 domain-containing protein	-
FEL04_RS13655	2853383..2853601	-	219	WP_000683609.1	DUF4014 family protein	-
FEL04_RS13660	2853729..2854040	-	312	WP_001289673.1	hypothetical protein	-
FEL04_RS13665	2854033..2854260	-	228	WP_000699809.1	hypothetical protein	-
FEL04_RS13670	2854257..2854538	-	282	WP_000603384.1	DNA-binding protein	-
FEL04_RS13675	2854571..2855287	-	717	WP_000450627.1	DUF1627 domain-containing protein	-
FEL04_RS13680	2855321..2855782	-	462	WP_000139447.1	replication protein	-
FEL04_RS13685	2855775..2856830	-	1056	WP_001356791.1	hypothetical protein	-
FEL04_RS13690	2856899..2857324	-	426	WP_000693878.1	Rha family transcriptional regulator	-
FEL04_RS13695	2857308..2857550	-	243	WP_000747948.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7'	2814930..2909767	94837

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7887.47 Da
• Isoelectric Point: 9.2654

>T125412 WP_000935259.1 NZ_CP040311:c2852590-2852378 [Escherichia coli]
MLNTCRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 213 bp

>T125412 NZ_CP040311:c2852590-2852378 [Escherichia coli]
ATGCTGAACACATGTAGGTTAGCCTCTTACGTGCCGAAAGGCAAGGAGAAGCAGGCTATGAAGCAGCAAAAGGCGATGTT
AATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAAAGACCTCTGCGAGGTGCGAATCC
GAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT125412 NZ_CP040311:2852545-2852603 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Antitoxin