Detailed information of TA system TA125405

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1930825..1931050
• Replicon: chromosome
• Accession: NZ_CP040311
• Organism: Escherichia coli strain F3398

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: FEL04_RS08870
• Protein ID: WP_000813263.1
• Coordinates: 1930895..1931050 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1930825..1930883 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEL04_RS08840	1926106..1927191	+	1086	WP_072141648.1	DNA-binding protein	-
FEL04_RS08845	1927198..1927944	+	747	WP_000788745.1	ATP-binding protein	-
FEL04_RS08850	1927966..1928736	+	771	WP_000450992.1	DUF1627 domain-containing protein	-
FEL04_RS08855	1928752..1929165	+	414	WP_001151233.1	DUF977 family protein	-
FEL04_RS08860	1929517..1930290	-	774	WP_000160654.1	alpha/beta hydrolase	-
-	1930825..1930883	-	59	-	-	Antitoxin
FEL04_RS08870	1930895..1931050	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
FEL04_RS08875	1931218..1931496	+	279	WP_001341388.1	hypothetical protein	-
FEL04_RS08880	1931498..1932547	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
FEL04_RS08885	1932560..1932931	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
FEL04_RS08890	1932921..1933292	+	372	WP_000090264.1	antitermination protein	-
FEL04_RS08895	1933444..1934262	+	819	WP_153023022.1	CPBP family intramembrane metalloprotease	-
FEL04_RS08900	1934549..1934745	+	197	Protein_1724	TrmB family transcriptional regulator	-
FEL04_RS08905	1934883..1935596	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T125405 WP_000813263.1 NZ_CP040311:1930895-1931050 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T125405 NZ_CP040311:1930895-1931050 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT125405 NZ_CP040311:c1930883-1930825 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin