125395

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 692704..693116 Replicon chromosome
Accession NZ_CP040311
Organism Escherichia coli strain F3398

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag FEL04_RS03155 Protein ID WP_000132630.1
Coordinates 692704..693045 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 693040..693116 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEL04_RS26800 688272..688472 + 201 WP_001310455.1 hypothetical protein -
FEL04_RS03135 688715..690127 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
FEL04_RS03140 690304..690468 + 165 WP_000394274.1 DUF1127 domain-containing protein -
FEL04_RS03145 690565..691446 + 882 WP_001304007.1 DUF262 domain-containing protein -
FEL04_RS03150 691494..692657 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
FEL04_RS03155 692704..693045 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- 693040..693116 + 77 NuclAT_14 - Antitoxin
- 693040..693116 + 77 NuclAT_14 - Antitoxin
- 693040..693116 + 77 NuclAT_14 - Antitoxin
- 693040..693116 + 77 NuclAT_14 - Antitoxin
- 693040..693116 + 77 NuclAT_15 - Antitoxin
- 693040..693116 + 77 NuclAT_15 - Antitoxin
- 693040..693116 + 77 NuclAT_15 - Antitoxin
- 693040..693116 + 77 NuclAT_15 - Antitoxin
FEL04_RS03160 693266..695020 - 1755 WP_000110082.1 restriction endonuclease subunit S -
FEL04_RS03165 695020..696489 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 682197..700917 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T125395 WP_000132630.1 NZ_CP040311:c693045-692704 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T125395 NZ_CP040311:c693045-692704 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT125395 NZ_CP040311:693040-693116 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References