Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1032594..1033133 Replicon chromosome
Accession NZ_CP040307
Organism Escherichia coli strain F1 E4

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag FEL01_RS04705 Protein ID WP_001303998.1
Coordinates 1032594..1032854 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag FEL01_RS04710 Protein ID WP_000729705.1
Coordinates 1032873..1033133 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEL01_RS04690 1030277..1030855 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
FEL01_RS04695 1030960..1031727 + 768 WP_001301698.1 class II glutamine amidotransferase -
FEL01_RS04700 1031698..1032438 - 741 WP_001225679.1 murein L,D-transpeptidase -
FEL01_RS04705 1032594..1032854 - 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
FEL01_RS04710 1032873..1033133 - 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
FEL01_RS04715 1033319..1034092 + 774 WP_000543891.1 C40 family peptidase -
FEL01_RS04720 1034268..1034765 + 498 Protein_906 REP-associated tyrosine transposase RayT -
FEL01_RS04725 1034910..1036649 - 1740 WP_001301901.1 flagellar biosynthesis protein FlhA -
FEL01_RS04730 1036594..1037379 + 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T125322 WP_001303998.1 NZ_CP040307:c1032854-1032594 [Escherichia coli]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T125322 NZ_CP040307:c1032854-1032594 [Escherichia coli]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT125322 WP_000729705.1 NZ_CP040307:c1033133-1032873 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT125322 NZ_CP040307:c1033133-1032873 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References