125304

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2452106..2452577 Replicon chromosome
Accession NZ_CP040305
Organism Escherichia coli strain HB6

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag FEL06_RS11790 Protein ID WP_001303511.1
Coordinates 2452106..2452384 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag FEL06_RS11795 Protein ID WP_001302048.1
Coordinates 2452386..2452577 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEL06_RS11750 2447112..2447296 - 185 Protein_2288 DUF3596 domain-containing protein -
FEL06_RS11755 2447331..2447582 - 252 WP_000005552.1 excisionase family protein -
FEL06_RS11760 2447655..2450126 - 2472 WP_000048458.1 exonuclease -
FEL06_RS11765 2450219..2450410 - 192 WP_001090200.1 DUF1482 family protein -
FEL06_RS11770 2450407..2450595 - 189 WP_000449192.1 cell division inhibition protein DicB -
FEL06_RS11780 2451164..2451382 - 219 WP_001171930.1 hypothetical protein -
FEL06_RS11785 2451454..2451753 - 300 WP_001240334.1 hypothetical protein -
FEL06_RS11790 2452106..2452384 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FEL06_RS11795 2452386..2452577 - 192 WP_001302048.1 hypothetical protein Antitoxin
FEL06_RS11800 2452598..2452969 - 372 WP_001169686.1 hypothetical protein -
FEL06_RS11805 2453067..2453369 + 303 WP_000172738.1 transcriptional regulator -
FEL06_RS11810 2453366..2453791 + 426 WP_000693943.1 Rha family transcriptional regulator -
FEL06_RS11815 2453814..2454776 + 963 WP_000095670.1 helix-turn-helix domain-containing protein -
FEL06_RS11820 2454783..2455523 + 741 WP_000788936.1 ATP-binding protein -
FEL06_RS11825 2455549..2456318 + 770 Protein_2302 DUF1627 domain-containing protein -
FEL06_RS11830 2456334..2456729 + 396 WP_001118159.1 DUF977 family protein -
FEL06_RS11835 2456786..2457370 + 585 WP_000206793.1 DUF551 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleG7' 2444945..2548511 103566


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T125304 WP_001303511.1 NZ_CP040305:c2452384-2452106 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T125304 NZ_CP040305:c2452384-2452106 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT125304 WP_001302048.1 NZ_CP040305:c2452577-2452386 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT125304 NZ_CP040305:c2452577-2452386 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References