Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1321425..1322031 Replicon chromosome
Accession NZ_CP040297
Organism Nostoc sp. TCL26-01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FD725_RS05615 Protein ID WP_179047215.1
Coordinates 1321747..1322031 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FD725_RS05610 Protein ID WP_179047214.1
Coordinates 1321425..1321733 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD725_RS05600 1320003..1320707 + 705 WP_179047212.1 CAP domain-containing protein -
FD725_RS05605 1320847..1321419 + 573 WP_179047213.1 CAP domain-containing protein -
FD725_RS05610 1321425..1321733 - 309 WP_179047214.1 HigA family addiction module antidote protein Antitoxin
FD725_RS05615 1321747..1322031 - 285 WP_179047215.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FD725_RS05620 1322189..1323016 + 828 WP_179047216.1 alpha/beta hydrolase -
FD725_RS05625 1323316..1323618 - 303 WP_179047217.1 DUF1816 domain-containing protein -
FD725_RS05630 1323718..1324875 - 1158 WP_179047218.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
FD725_RS05635 1324973..1325425 - 453 WP_179047219.1 ribonuclease III -
FD725_RS05640 1325690..1326091 - 402 WP_179047220.1 STAS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(14-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-93)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10957.52 Da        Isoelectric Point: 5.8347

>T125284 WP_179047215.1 NZ_CP040297:c1322031-1321747 [Nostoc sp. TCL26-01]
VIIGFKTEETKLIFDGFTSPSYPQEIQKVALRKLLMLNAAVSINDLRTPPGNRLEKLVGNRQGQYSIRINDKWRICFFWT
DENNVDEVEIVDYH

Download         Length: 285 bp

>T125284 NZ_CP040297:c1322031-1321747 [Nostoc sp. TCL26-01]
GTGATTATAGGTTTCAAAACTGAAGAAACAAAACTCATTTTTGATGGTTTTACGTCTCCTTCTTACCCTCAAGAAATTCA
AAAAGTTGCTTTAAGAAAGCTGCTAATGTTGAATGCGGCAGTATCAATTAACGATCTTCGCACTCCACCTGGTAATCGGT
TAGAAAAGCTAGTTGGAAACAGACAAGGACAATATAGTATTCGGATTAATGATAAGTGGCGAATTTGCTTTTTCTGGACA
GATGAAAATAATGTAGATGAGGTGGAAATAGTAGATTACCATTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11768.39 Da        Isoelectric Point: 5.0492

>AT125284 WP_179047214.1 NZ_CP040297:c1321733-1321425 [Nostoc sp. TCL26-01]
MDDNRLSNIHPGEILQLEFLEPLNITPYRLSKDIGVSQTRISEILSGKRTITADTALRLSRYFGNSAQFWLNLQIEYDLR
QALAENADMYNQILIRPFTNVP

Download         Length: 309 bp

>AT125284 NZ_CP040297:c1321733-1321425 [Nostoc sp. TCL26-01]
ATGGACGATAACCGTTTATCAAACATTCATCCAGGCGAAATTCTGCAACTAGAATTTTTAGAGCCATTAAATATTACTCC
CTATCGATTGAGTAAAGATATAGGTGTATCTCAGACACGGATTAGTGAAATCTTATCTGGAAAACGCACAATTACGGCAG
ATACGGCCTTGCGTCTATCCCGCTATTTTGGTAACAGCGCTCAGTTTTGGTTGAATTTGCAAATAGAATATGATTTACGT
CAAGCATTAGCAGAAAATGCGGATATGTATAATCAAATTCTGATTAGACCGTTTACTAATGTACCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References