Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 290209..290810 Replicon chromosome
Accession NZ_CP040297
Organism Nostoc sp. TCL26-01

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FD725_RS01200 Protein ID WP_179046444.1
Coordinates 290511..290810 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FD725_RS01195 Protein ID WP_179046443.1
Coordinates 290209..290499 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD725_RS01155 286354..286773 - 420 WP_179051376.1 PIN domain-containing protein -
FD725_RS01160 286777..287073 - 297 WP_179046437.1 helix-turn-helix domain-containing protein -
FD725_RS01165 287036..287251 - 216 WP_179046438.1 hypothetical protein -
FD725_RS01170 287309..288025 + 717 WP_179046439.1 SDR family oxidoreductase -
FD725_RS01175 288594..289193 + 600 WP_179046440.1 tRNA-(ms[2]io[6]A)-hydroxylase -
FD725_RS01180 289211..289612 + 402 WP_179046441.1 VOC family protein -
FD725_RS01185 289622..289957 - 336 WP_179046442.1 XisI protein -
FD725_RS01190 290010..290081 - 72 Protein_236 fatty-acid oxidation protein subunit alpha -
FD725_RS01195 290209..290499 - 291 WP_179046443.1 HigA family addiction module antidote protein Antitoxin
FD725_RS01200 290511..290810 - 300 WP_179046444.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FD725_RS01205 291090..291569 + 480 WP_179046445.1 GNAT family N-acetyltransferase -
FD725_RS01210 291600..291959 + 360 WP_179046446.1 VOC family protein -
FD725_RS01215 292108..292662 - 555 WP_179046447.1 hypothetical protein -
FD725_RS01220 292914..294194 - 1281 WP_179046448.1 acetyltransferase -
FD725_RS01225 294373..294600 - 228 WP_179046449.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-99)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-80)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11825.20 Da        Isoelectric Point: 5.2063

>T125282 WP_179046444.1 NZ_CP040297:c290810-290511 [Nostoc sp. TCL26-01]
MSSSDEYPKYKDKKTEKFALGERVREFQSFERQAQKRLDILEAAPNKEALMQLPSNRFESLGGDRTGQYSIRINDQWRIC
FNWPDDFLQPFNIEITDYH

Download         Length: 300 bp

>T125282 NZ_CP040297:c290810-290511 [Nostoc sp. TCL26-01]
ATGTCTTCGTCAGATGAATACCCTAAATACAAAGATAAAAAGACGGAGAAATTCGCTTTAGGAGAAAGGGTTAGAGAATT
TCAATCTTTTGAAAGACAGGCGCAGAAACGACTTGATATCTTAGAAGCAGCCCCTAACAAAGAAGCTTTAATGCAATTAC
CAAGCAATCGTTTTGAATCATTGGGAGGAGATAGAACAGGTCAGTACAGCATCCGAATTAATGATCAATGGAGAATTTGT
TTTAACTGGCCTGATGATTTTCTTCAACCCTTCAATATAGAAATTACAGATTATCACTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10621.26 Da        Isoelectric Point: 7.2026

>AT125282 WP_179046443.1 NZ_CP040297:c290499-290209 [Nostoc sp. TCL26-01]
MARPPIHPGEILADELTELGMSASDLARVLHVPKNRITEIINGKRGITADTALRLGQYFGTGGELWLNLQKNYELKLAQQ
TLGKTIEETILPRVQS

Download         Length: 291 bp

>AT125282 NZ_CP040297:c290499-290209 [Nostoc sp. TCL26-01]
ATGGCGCGTCCACCTATCCATCCTGGAGAGATTCTGGCTGATGAACTTACAGAACTTGGGATGAGCGCGAGTGATTTGGC
TCGTGTTCTCCATGTTCCTAAAAATAGAATCACCGAAATTATTAATGGAAAAAGGGGAATAACAGCTGATACAGCTTTGC
GATTAGGACAATATTTCGGAACTGGTGGAGAATTATGGTTAAATCTTCAGAAGAACTATGAGCTGAAGCTAGCTCAACAA
ACACTAGGTAAAACAATTGAGGAAACAATTCTACCTCGTGTACAGAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References