Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5039346..5039971 Replicon chromosome
Accession NZ_CP040272
Organism Nostoc sp. C052

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FD723_RS20785 Protein ID WP_179067040.1
Coordinates 5039346..5039648 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FD723_RS20790 Protein ID WP_179067041.1
Coordinates 5039660..5039971 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD723_RS20755 5034786..5035673 + 888 WP_179067035.1 ABC transporter permease -
FD723_RS20760 5035710..5036108 + 399 WP_179067036.1 hypothetical protein -
FD723_RS20765 5036187..5036624 - 438 WP_179067037.1 peroxiredoxin -
FD723_RS20770 5036819..5037223 + 405 WP_179067038.1 hypothetical protein -
FD723_RS20775 5037441..5038925 + 1485 WP_179067039.1 cobyric acid synthase CobQ -
FD723_RS20780 5039008..5039244 + 237 WP_069073076.1 (2Fe-2S)-binding protein -
FD723_RS20785 5039346..5039648 + 303 WP_179067040.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FD723_RS20790 5039660..5039971 + 312 WP_179067041.1 HigA family addiction module antidote protein Antitoxin
FD723_RS20795 5040069..5040281 + 213 WP_179067042.1 type II toxin-antitoxin system HicA family toxin -
FD723_RS20800 5040274..5040492 + 219 WP_179067043.1 type II toxin-antitoxin system HicB family antitoxin -
FD723_RS20805 5040567..5041010 - 444 WP_179067044.1 SRPBCC family protein -
FD723_RS20810 5041055..5042494 - 1440 WP_179067045.1 9,9'-di-cis-zeta-carotene desaturase -
FD723_RS20815 5042771..5042947 - 177 WP_179067046.1 CopG family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-64)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11962.47 Da        Isoelectric Point: 8.0127

>T125272 WP_179067040.1 NZ_CP040272:5039346-5039648 [Nostoc sp. C052]
MSPSDKYPKFKDKRTERFALGERVKEFQAFTDQAYKRLDILDAATNKESLMKLPSNHFESLEGDRKGQYSIRINKQWRIC
FNWPDEESKPFNIEITDYHP

Download         Length: 303 bp

>T125272 NZ_CP040272:5039346-5039648 [Nostoc sp. C052]
ATGTCTCCGTCAGACAAGTATCCAAAATTTAAAGATAAAAGGACGGAGCGGTTTGCTTTAGGTGAGAGGGTCAAGGAGTT
TCAGGCTTTTACAGACCAAGCATACAAACGACTTGATATATTAGATGCCGCTACTAACAAAGAATCTTTGATGAAACTAC
CGAGCAACCATTTTGAGTCTTTAGAGGGTGATCGAAAAGGTCAATATAGCATTCGGATCAATAAGCAATGGCGAATTTGT
TTCAATTGGCCAGACGAAGAATCTAAACCTTTCAACATCGAAATTACAGACTATCATCCTTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11649.39 Da        Isoelectric Point: 5.6421

>AT125272 WP_179067041.1 NZ_CP040272:5039660-5039971 [Nostoc sp. C052]
MARPPIHPGKILADELHELQMSASELARILHVPTNRITEIINGERAITADTALRLGQWFGTGAELWMNLQKNYELRLAEE
KMGEEIQATISPRILSEYKQVNA

Download         Length: 312 bp

>AT125272 NZ_CP040272:5039660-5039971 [Nostoc sp. C052]
ATGGCACGGCCACCCATCCATCCTGGAAAAATTCTTGCTGATGAGCTTCATGAATTGCAGATGAGTGCAAGTGAGTTAGC
ACGTATCCTTCATGTACCAACAAATCGTATTACTGAAATAATTAATGGTGAACGGGCAATTACTGCTGATACAGCATTAC
GATTGGGTCAATGGTTTGGTACTGGTGCAGAGTTGTGGATGAATTTACAAAAGAATTATGAGCTTAGACTAGCTGAAGAA
AAAATGGGTGAAGAAATTCAGGCAACTATTTCGCCCCGGATATTATCTGAGTACAAGCAAGTCAATGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References