Detailed information of TA system TA125193

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1682551..1683260
• Replicon: chromosome
• Accession: NZ_CP040255
• Organism: Mycobacterium avium subsp. hominissuis strain 101115

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: X7V9P5
• Locus tag: FCV18_RS08700
• Protein ID: WP_003873387.1
• Coordinates: 1682551..1682955 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: HigA2
• Uniprot ID: X7V856
• Locus tag: FCV18_RS08705
• Protein ID: WP_019732445.1
• Coordinates: 1682952..1683260 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCV18_RS08675	1677868..1678446	-	579	WP_011726026.1	sigma-70 family RNA polymerase sigma factor	-
FCV18_RS08680	1678537..1679364	-	828	WP_062886661.1	hypothetical protein	-
FCV18_RS08685	1679762..1680070	+	309	WP_003874400.1	WhiB family transcriptional regulator	-
FCV18_RS08690	1680113..1680877	+	765	WP_062886662.1	superoxide dismutase family protein	-
FCV18_RS08695	1681034..1682233	-	1200	WP_081216150.1	FAD-dependent oxidoreductase	-
FCV18_RS08700	1682551..1682955	+	405	WP_003873387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FCV18_RS08705	1682952..1683260	+	309	WP_019732445.1	helix-turn-helix transcriptional regulator	Antitoxin
FCV18_RS08715	1683747..1685273	-	1527	WP_019732444.1	adenylate/guanylate cyclase domain-containing protein	-
FCV18_RS08720	1685368..1686984	-	1617	WP_003873390.1	chaperonin GroEL	-
FCV18_RS08725	1687073..1687375	-	303	WP_019732443.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (32-91)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15503.82 Da
• Isoelectric Point: 10.3815

>T125193 WP_003873387.1 NZ_CP040255:1682551-1682955 [Mycobacterium avium subsp. hominissuis]
VRKWEVDLTLIEAWMDALDDEEYDNLIAALEQLEEHGPITRRPFVDTLEGSRHPNMKELRPRPTKAGAHIRVLFAFDTRS
RAIMLIAGDKAGNWSKWYAKHIPIADELFDAHQKRLHKAAAKATNRKPRKGKKR

Nucleotide

• Length: 405 bp

>T125193 NZ_CP040255:1682551-1682955 [Mycobacterium avium subsp. hominissuis]
GTGCGGAAATGGGAGGTTGACCTGACTCTCATCGAAGCCTGGATGGACGCCCTCGATGACGAGGAGTACGACAACTTGAT
AGCAGCGCTCGAGCAGTTGGAGGAACACGGTCCAATTACCCGGCGGCCGTTTGTGGACACCCTTGAAGGGTCACGGCACC
CGAACATGAAGGAGCTCCGTCCGCGCCCCACGAAAGCTGGAGCCCACATTCGCGTGCTATTCGCCTTCGATACCCGGTCG
CGGGCGATCATGTTGATCGCTGGAGACAAGGCGGGGAATTGGTCCAAGTGGTATGCCAAGCACATTCCCATTGCCGACGA
GCTCTTCGATGCTCACCAAAAGCGTTTGCACAAGGCAGCAGCCAAAGCCACAAATCGGAAACCAAGGAAGGGTAAGAAAC
GATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11454.95 Da
• Isoelectric Point: 10.0802

>AT125193 WP_019732445.1 NZ_CP040255:1682952-1683260 [Mycobacterium avium subsp. hominissuis]
MTNLDDMRRRRPGNRTRIDAIKAEMDREVAHYRLRELREAAGYTQTTLAAAIGVGQNRVSQMEHGDLGTSRVDTLRKYVE
ATGGELEVSVKRPDGSRVLLSL

Nucleotide

• Length: 309 bp

>AT125193 NZ_CP040255:1682952-1683260 [Mycobacterium avium subsp. hominissuis]
ATGACCAATCTTGATGACATGCGCCGTCGCCGTCCCGGCAACCGGACCCGTATCGACGCGATCAAGGCGGAGATGGACCG
CGAGGTTGCCCACTACCGTCTCCGTGAACTGCGCGAGGCTGCCGGCTACACGCAGACGACTCTCGCTGCGGCTATTGGCG
TCGGGCAGAACCGCGTCTCGCAGATGGAACATGGCGATCTCGGCACCAGCCGGGTCGACACTCTCCGCAAGTACGTGGAA
GCGACTGGGGGTGAGCTGGAAGTGTCCGTCAAGCGTCCGGACGGGTCACGGGTTCTCCTCAGTCTGTAA

Structures

Toxin

• AlphaFold DB: X7V9P5

Antitoxin

• AlphaFold DB: X7V856