Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2792970..2793384 Replicon chromosome
Accession NZ_CP040233
Organism Staphylococcus aureus strain GD1696

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FD747_RS13670 Protein ID WP_031886311.1
Coordinates 2792970..2793221 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FD747_RS13675 Protein ID WP_000028424.1
Coordinates 2793211..2793384 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD747_RS13615 2788172..2790124 + 1953 WP_001796208.1 DNA polymerase -
FD747_RS13620 2790137..2790322 + 186 WP_001164628.1 DUF3113 family protein -
FD747_RS13625 2790322..2790723 + 402 WP_000113981.1 PVL family protein -
FD747_RS13630 2790723..2790980 + 258 WP_000111488.1 DUF3310 domain-containing protein -
FD747_RS13635 2790983..2791183 + 201 WP_031796775.1 hypothetical protein -
FD747_RS13640 2791192..2791440 + 249 WP_000178883.1 phi PVL orf 51-like protein -
FD747_RS13645 2791455..2791661 + 207 WP_000693993.1 hypothetical protein -
FD747_RS13650 2791664..2792071 + 408 WP_000695771.1 hypothetical protein -
FD747_RS13655 2792068..2792262 + 195 WP_031794818.1 hypothetical protein -
FD747_RS13660 2792259..2792696 + 438 WP_031796778.1 hypothetical protein -
FD747_RS13665 2792693..2792977 + 285 WP_031886310.1 hypothetical protein -
FD747_RS13670 2792970..2793221 + 252 WP_031886311.1 DUF1024 family protein Toxin
FD747_RS13675 2793211..2793384 + 174 WP_000028424.1 hypothetical protein Antitoxin
FD747_RS13680 2793385..2793546 + 162 WP_000889680.1 hypothetical protein -
FD747_RS13685 2793561..2794067 + 507 WP_001061834.1 dUTPase -
FD747_RS13690 2794104..2794310 + 207 WP_031886312.1 DUF1381 domain-containing protein -
FD747_RS13695 2794307..2794501 + 195 WP_000141184.1 hypothetical protein -
FD747_RS13700 2794498..2794701 + 204 WP_001072795.1 hypothetical protein -
FD747_RS13705 2794694..2794846 + 153 WP_031767608.1 transcriptional activator RinB -
FD747_RS13710 2794914..2795114 + 201 WP_031886313.1 DUF1514 family protein -
FD747_RS13715 2795166..2797613 + 2448 WP_031886314.1 virulence-associated E family protein -
FD747_RS13720 2797715..2797819 - 105 WP_078098968.1 hypothetical protein -
FD747_RS13725 2797953..2798243 + 291 WP_000665205.1 VRR-NUC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2780128..2800945 20817


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.28 Da        Isoelectric Point: 3.8567

>T125148 WP_031886311.1 NZ_CP040233:2792970-2793221 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T125148 NZ_CP040233:2792970-2793221 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATACAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT125148 WP_000028424.1 NZ_CP040233:2793211-2793384 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT125148 NZ_CP040233:2793211-2793384 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References