Detailed information of TA system TA125145

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2784267..2784846
• Replicon: chromosome
• Accession: NZ_CP040233
• Organism: Staphylococcus aureus strain GD1696

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: FD747_RS13570
• Protein ID: WP_001025401.1
• Coordinates: 2784267..2784512 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2784481..2784846 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD747_RS13535	2780011..2781216	-	1206	Protein_2628	site-specific integrase	-
FD747_RS13540	2781326..2781949	+	624	WP_001166482.1	hypothetical protein	-
FD747_RS13545	2782147..2782542	-	396	WP_000449655.1	hypothetical protein	-
FD747_RS13550	2782571..2783005	-	435	WP_000755721.1	hypothetical protein	-
FD747_RS13555	2783023..2783484	-	462	WP_031886309.1	toxin	-
FD747_RS13560	2783497..2783826	-	330	WP_000429766.1	helix-turn-helix domain-containing protein	-
FD747_RS13565	2783987..2784178	+	192	WP_001115060.1	helix-turn-helix domain-containing protein	-
FD747_RS13570	2784267..2784512	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
FD747_RS13575	2784481..2784846	-	366	WP_001128433.1	hypothetical protein	Antitoxin
FD747_RS13580	2784901..2785116	+	216	WP_001036302.1	hypothetical protein	-
FD747_RS13585	2785141..2785404	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
FD747_RS13590	2785417..2785578	+	162	WP_001285963.1	DUF1270 family protein	-
FD747_RS13595	2785657..2785980	+	324	WP_000175000.1	hypothetical protein	-
FD747_RS13600	2785995..2786357	+	363	WP_000279445.1	hypothetical protein	-
FD747_RS13605	2786354..2787520	+	1167	WP_000762532.1	DUF2800 domain-containing protein	-
FD747_RS13610	2787546..2788103	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2780128..2800945	20817

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T125145 WP_001025401.1 NZ_CP040233:2784267-2784512 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T125145 NZ_CP040233:2784267-2784512 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT125145 NZ_CP040233:c2784846-2784481 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin