Detailed information of TA system TA125137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 768460..768874
• Replicon: chromosome
• Accession: NZ_CP040233
• Organism: Staphylococcus aureus strain GD1696

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A6B5KJM6
• Locus tag: FD747_RS03895
• Protein ID: WP_001065110.1
• Coordinates: 768460..768711 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FD747_RS03900
• Protein ID: WP_000028424.1
• Coordinates: 768701..768874 (+)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD747_RS03830	763871..764020	+	150	WP_001081083.1	hypothetical protein	-
FD747_RS03835	764013..764294	-	282	WP_031902973.1	hypothetical protein	-
FD747_RS03840	764360..765130	+	771	WP_000190224.1	conserved phage C-terminal domain-containing protein	-
FD747_RS03845	765140..765919	+	780	WP_017804692.1	ATP-binding protein	-
FD747_RS03850	765913..766071	+	159	WP_000256594.1	hypothetical protein	-
FD747_RS03855	766084..766305	+	222	WP_001123695.1	DUF3269 family protein	-
FD747_RS03860	766315..766719	+	405	WP_138765647.1	DUF1064 domain-containing protein	-
FD747_RS03865	766724..766912	+	189	WP_138765648.1	DUF3113 family protein	-
FD747_RS03870	766913..767170	+	258	WP_031903678.1	helix-turn-helix transcriptional regulator	-
FD747_RS03875	767183..767542	+	360	WP_138765649.1	hypothetical protein	-
FD747_RS03880	767543..767791	+	249	WP_031902402.1	phi PVL orf 51-like protein	-
FD747_RS03885	767806..768207	+	402	WP_031901024.1	hypothetical protein	-
FD747_RS03890	768204..768467	+	264	WP_138765650.1	hypothetical protein	-
FD747_RS03895	768460..768711	+	252	WP_001065110.1	DUF1024 family protein	Toxin
FD747_RS03900	768701..768874	+	174	WP_000028424.1	hypothetical protein	Antitoxin
FD747_RS03905	768875..769036	+	162	WP_000889682.1	hypothetical protein	-
FD747_RS03910	769051..769584	+	534	WP_021286125.1	dUTPase	-
FD747_RS03915	769621..769827	+	207	WP_138765651.1	DUF1381 domain-containing protein	-
FD747_RS03920	769824..770018	+	195	WP_031904648.1	hypothetical protein	-
FD747_RS03925	770015..770218	+	204	WP_106095086.1	hypothetical protein	-
FD747_RS03930	770211..770448	+	238	Protein_764	hypothetical protein	-
FD747_RS03935	770441..770614	+	174	WP_138765652.1	transcriptional activator RinB	-
FD747_RS03940	770615..770761	+	147	WP_000989998.1	hypothetical protein	-
FD747_RS03945	770776..771195	+	420	WP_031764172.1	transcriptional regulator	-
FD747_RS03950	771382..771876	+	495	WP_031903208.1	terminase small subunit	-
FD747_RS03955	771879..773168	+	1290	WP_031887157.1	PBSX family phage terminase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	753713..798346	44633

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9405.32 Da
• Isoelectric Point: 3.8051

>T125137 WP_001065110.1 NZ_CP040233:768460-768711 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T125137 NZ_CP040233:768460-768711 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCGAGCATTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6468.29 Da
• Isoelectric Point: 4.2484

>AT125137 WP_000028424.1 NZ_CP040233:768701-768874 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT125137 NZ_CP040233:768701-768874 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Structures

Toxin

• AlphaFold DB: A0A6B5KJM6