Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprG3-SprA2AS/-
Location 2272151..2272349 Replicon chromosome
Accession NZ_CP040232
Organism Staphylococcus aureus strain GD1706

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag FD746_RS11510 Protein ID WP_001802298.1
Coordinates 2272245..2272349 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2272151..2272189 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD746_RS11490 2268271..2268936 - 666 WP_001024099.1 SDR family oxidoreductase -
FD746_RS11495 2269088..2269408 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
FD746_RS11500 2269410..2270390 + 981 WP_031886446.1 CDF family zinc efflux transporter CzrB -
FD746_RS11505 2270656..2271747 + 1092 WP_000495673.1 hypothetical protein -
- 2272151..2272189 + 39 - - Antitoxin
FD746_RS11510 2272245..2272349 - 105 WP_001802298.1 hypothetical protein Toxin
FD746_RS11525 2273029..2273187 + 159 WP_001792784.1 hypothetical protein -
FD746_RS11530 2273623..2273715 + 93 WP_000220902.1 hypothetical protein -
FD746_RS11535 2273845..2274702 - 858 WP_000370942.1 Cof-type HAD-IIB family hydrolase -
FD746_RS11540 2274770..2275552 - 783 WP_000908191.1 ABC transporter ATP-binding protein -
FD746_RS11545 2275842..2276450 - 609 WP_000101714.1 TIR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T125133 WP_001802298.1 NZ_CP040232:c2272349-2272245 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T125133 NZ_CP040232:c2272349-2272245 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 39 bp

>AT125133 NZ_CP040232:2272151-2272189 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References