Detailed information of TA system TA125127

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 1209537..1210012
• Replicon: chromosome
• Accession: NZ_CP040232
• Organism: Staphylococcus aureus strain GD1706

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: FD746_RS06190
• Protein ID: WP_000387655.1
• Coordinates: 1209710..1210012 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1209537..1209661 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD746_RS06160	1204559..1208341	+	3783	WP_031901052.1	phage minor structural protein	-
FD746_RS06165	1208334..1208486	+	153	WP_001000058.1	hypothetical protein	-
FD746_RS06170	1208532..1208819	+	288	WP_031901053.1	hypothetical protein	-
FD746_RS06175	1208877..1209173	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
FD746_RS06180	1209365..1209512	+	148	Protein_1186	putative holin-like toxin	-
-	1209537..1209661	-	125	-	-	Antitoxin
FD746_RS06190	1209710..1210012	+	303	WP_000387655.1	phage holin	Toxin
FD746_RS06195	1210023..1211477	+	1455	WP_000930251.1	N-acetylmuramoyl-L-alanine amidase	-
FD746_RS06200	1211822..1212562	+	741	WP_000185611.1	CPBP family intramembrane metalloprotease	-
FD746_RS06215	1213246..1213580	+	335	Protein_1191	SH3 domain-containing protein	-
FD746_RS06220	1213675..1214124	-	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	chp / scn	1151610..1217207	65597

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11127.85 Da
• Isoelectric Point: 9.6587

>T125127 WP_000387655.1 NZ_CP040232:1209710-1210012 [Staphylococcus aureus]
MEAKVITRYIVLILALVNQFLANKGISPIPVDEESVSSIILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPVKEVIAPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T125127 NZ_CP040232:1209710-1210012 [Staphylococcus aureus]
ATGGAAGCAAAAGTAATAACAAGATATATTGTATTAATTTTAGCATTAGTCAATCAGTTTTTAGCGAATAAAGGTATAAG
TCCGATACCAGTAGATGAAGAAAGTGTTTCATCGATTATCTTAACAGTTATTGCTTTATACACTACGTATAAAGACAATC
CAACATCACAAGAAGGACGTTGGGCGAATCAAAAATTAAAGAAATATAAAGCTGAAAGTAAATATAGAAAAGCAACAGGT
CAAGCACCTGTCAAAGAAGTAATAGCACCTACAAATATGAACGATACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 125 bp

>AT125127 NZ_CP040232:c1209661-1209537 [Staphylococcus aureus]
ATTTGATATTTATATTATGATGTGTTAATTTATATATAGAAAAAGGGCAACATGCGGAAACATGTCACCCTAGTGAGCCC
GTTAAAAAGACGGTGACCTCTTTTATATGATTAATAAATAACCAT

Structures

Antitoxin