Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 929417..929831 Replicon chromosome
Accession NZ_CP040232
Organism Staphylococcus aureus strain GD1706

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FD746_RS04645 Protein ID WP_031901025.1
Coordinates 929417..929668 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FD746_RS14565 Protein ID WP_000028424.1
Coordinates 929658..929831 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD746_RS04585 925024..925380 + 357 WP_031887099.1 hypothetical protein -
FD746_RS04590 925377..926618 + 1242 WP_031887100.1 AAA family ATPase -
FD746_RS04595 926615..926830 + 216 WP_001024406.1 hypothetical protein -
FD746_RS04600 926833..927054 + 222 WP_001123688.1 DUF3269 family protein -
FD746_RS04605 927065..927469 + 405 WP_031887101.1 DUF1064 domain-containing protein -
FD746_RS04610 927474..927659 + 186 WP_001187242.1 DUF3113 family protein -
FD746_RS04615 927660..928031 + 372 WP_031887102.1 phage protein -
FD746_RS04620 928031..928288 + 258 WP_031887103.1 DUF3310 domain-containing protein -
FD746_RS04625 928291..928491 + 201 WP_031887104.1 hypothetical protein -
FD746_RS04630 928506..928748 + 243 WP_031887105.1 phage protein -
FD746_RS04635 928763..929164 + 402 WP_031901024.1 hypothetical protein -
FD746_RS04640 929161..929424 + 264 WP_031887107.1 hypothetical protein -
FD746_RS04645 929417..929668 + 252 WP_031901025.1 DUF1024 family protein Toxin
FD746_RS14565 929658..929831 + 174 WP_000028424.1 hypothetical protein Antitoxin
FD746_RS14570 929832..929993 + 162 WP_000889682.1 hypothetical protein -
FD746_RS04650 930008..930541 + 534 WP_021286125.1 dUTPase -
FD746_RS04655 930578..930766 + 189 WP_149888473.1 DUF1381 domain-containing protein -
FD746_RS04660 930780..930974 + 195 WP_031904648.1 hypothetical protein -
FD746_RS04665 930971..931174 + 204 WP_001072794.1 hypothetical protein -
FD746_RS04670 931167..931403 + 237 WP_000608278.1 hypothetical protein -
FD746_RS04675 931393..931782 + 390 WP_001596346.1 hypothetical protein -
FD746_RS04680 931779..931952 + 174 WP_031902440.1 transcriptional activator RinB -
FD746_RS04685 931953..932099 + 147 WP_000989998.1 hypothetical protein -
FD746_RS04690 932114..932533 + 420 WP_000058634.1 transcriptional regulator -
FD746_RS04695 932720..933214 + 495 WP_149888474.1 terminase small subunit -
FD746_RS04700 933217..934506 + 1290 WP_031887157.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 916860..976418 59558


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9447.40 Da        Isoelectric Point: 3.8051

>T125125 WP_031901025.1 NZ_CP040232:929417-929668 [Staphylococcus aureus]
MNNREQIEQSIISASVYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T125125 NZ_CP040232:929417-929668 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGTCTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCGAGCATTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT125125 WP_000028424.1 NZ_CP040232:929658-929831 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT125125 NZ_CP040232:929658-929831 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References