Detailed information of TA system TA125124

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 405204..405618
• Replicon: chromosome
• Accession: NZ_CP040232
• Organism: Staphylococcus aureus strain GD1706

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FD746_RS01925
• Protein ID: WP_031886311.1
• Coordinates: 405204..405455 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FD746_RS14545
• Protein ID: WP_000028424.1
• Coordinates: 405445..405618 (+)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD746_RS01870	400406..402358	+	1953	WP_001796208.1	DNA polymerase	-
FD746_RS01875	402371..402556	+	186	WP_001164628.1	DUF3113 family protein	-
FD746_RS01880	402556..402957	+	402	WP_000113981.1	PVL family protein	-
FD746_RS01885	402957..403214	+	258	WP_000111488.1	DUF3310 domain-containing protein	-
FD746_RS01890	403217..403417	+	201	WP_031796775.1	hypothetical protein	-
FD746_RS01895	403426..403674	+	249	WP_149888451.1	phi PVL orf 51-like protein	-
FD746_RS01900	403689..403895	+	207	WP_000693993.1	hypothetical protein	-
FD746_RS01905	403898..404305	+	408	WP_000695771.1	hypothetical protein	-
FD746_RS01910	404302..404496	+	195	WP_031794818.1	hypothetical protein	-
FD746_RS01915	404493..404930	+	438	WP_031796778.1	hypothetical protein	-
FD746_RS01920	404927..405211	+	285	WP_031886310.1	hypothetical protein	-
FD746_RS01925	405204..405455	+	252	WP_031886311.1	DUF1024 family protein	Toxin
FD746_RS14545	405445..405618	+	174	WP_000028424.1	hypothetical protein	Antitoxin
FD746_RS14550	405619..405780	+	162	WP_000889680.1	hypothetical protein	-
FD746_RS01930	405795..406301	+	507	WP_001061834.1	dUTPase	-
FD746_RS01935	406338..406544	+	207	WP_031886312.1	DUF1381 domain-containing protein	-
FD746_RS01940	406541..406735	+	195	WP_000141184.1	hypothetical protein	-
FD746_RS01945	406732..406935	+	204	WP_001072795.1	hypothetical protein	-
FD746_RS01950	406928..407080	+	153	WP_031767608.1	transcriptional activator RinB	-
FD746_RS01955	407148..407348	+	201	WP_031886313.1	DUF1514 family protein	-
FD746_RS01960	407400..409847	+	2448	WP_031886314.1	virulence-associated E family protein	-
FD746_RS01970	409949..410053	-	105	WP_078098968.1	hypothetical protein	-
FD746_RS01975	410187..410477	+	291	WP_000665205.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	387689..437627	49938

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9405.28 Da
• Isoelectric Point: 3.8567

>T125124 WP_031886311.1 NZ_CP040232:405204-405455 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMTGQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T125124 NZ_CP040232:405204-405455 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATACAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6468.29 Da
• Isoelectric Point: 4.2484

>AT125124 WP_000028424.1 NZ_CP040232:405445-405618 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT125124 NZ_CP040232:405445-405618 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA