Detailed information of TA system TA125121

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 396501..397080
• Replicon: chromosome
• Accession: NZ_CP040232
• Organism: Staphylococcus aureus strain GD1706

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: FD746_RS01825
• Protein ID: WP_001025401.1
• Coordinates: 396501..396746 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	396715..397080 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD746_RS01790	392245..393450	-	1206	WP_031883891.1	site-specific integrase	-
FD746_RS01795	393560..394183	+	624	WP_001166482.1	hypothetical protein	-
FD746_RS01800	394381..394776	-	396	WP_000449655.1	hypothetical protein	-
FD746_RS01805	394805..395239	-	435	WP_000755721.1	hypothetical protein	-
FD746_RS01810	395257..395718	-	462	WP_031886309.1	toxin	-
FD746_RS01815	395731..396060	-	330	WP_000429766.1	helix-turn-helix domain-containing protein	-
FD746_RS01820	396221..396412	+	192	WP_001115060.1	helix-turn-helix domain-containing protein	-
FD746_RS01825	396501..396746	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
FD746_RS01830	396715..397080	-	366	WP_001128433.1	hypothetical protein	Antitoxin
FD746_RS01835	397135..397350	+	216	WP_001036302.1	hypothetical protein	-
FD746_RS01840	397375..397638	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
FD746_RS01845	397651..397812	+	162	WP_001285963.1	DUF1270 family protein	-
FD746_RS01850	397891..398214	+	324	WP_000175000.1	hypothetical protein	-
FD746_RS01855	398229..398591	+	363	WP_000279445.1	hypothetical protein	-
FD746_RS01860	398588..399754	+	1167	WP_000762532.1	DUF2800 domain-containing protein	-
FD746_RS01865	399780..400337	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	387689..437627	49938

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T125121 WP_001025401.1 NZ_CP040232:396501-396746 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T125121 NZ_CP040232:396501-396746 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT125121 NZ_CP040232:c397080-396715 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin