Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1471632..1472144 Replicon chromosome
Accession NZ_CP040231
Organism Streptococcus sp. 1643

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag FD735_RS07735 Protein ID WP_139658890.1
Coordinates 1471632..1471886 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag FD735_RS07740 Protein ID WP_176553065.1
Coordinates 1471890..1472144 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD735_RS07720 1468716..1469030 - 315 WP_002874282.1 DNA-directed RNA polymerase subunit omega -
FD735_RS07725 1469055..1469681 - 627 WP_000775041.1 guanylate kinase -
FD735_RS07730 1469816..1471429 - 1614 WP_000404963.1 ribonuclease Y -
FD735_RS07735 1471632..1471886 - 255 WP_139658890.1 Txe/YoeB family addiction module toxin Toxin
FD735_RS07740 1471890..1472144 - 255 WP_176553065.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FD735_RS07745 1472277..1473374 - 1098 WP_139658891.1 nucleotidyltransferase -
FD735_RS07750 1473384..1474130 - 747 WP_081103372.1 class I SAM-dependent methyltransferase -
FD735_RS07760 1474445..1474798 - 354 WP_139658892.1 ribosome silencing factor -
FD735_RS07765 1474799..1475392 - 594 WP_139658893.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
FD735_RS07770 1475392..1476021 - 630 WP_000963713.1 nicotinate-nucleotide adenylyltransferase -
FD735_RS07775 1476074..1476385 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10083.49 Da        Isoelectric Point: 7.9716

>T125120 WP_139658890.1 NZ_CP040231:c1471886-1471632 [Streptococcus sp. 1643]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFSGIGKPEPLKYDYQGAWSRRIDAENRLIYMIDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T125120 NZ_CP040231:c1471886-1471632 [Streptococcus sp. 1643]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTATTGGCAAAACCAAGATAAGAAAACATTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGCGATCCTTTTTCAGGAATAGGTAAACCAGAGCCACTCAAGTATGACTACCAAG
GAGCTTGGTCACGGCGCATTGATGCAGAAAATCGCTTGATTTATATGATAGATGGAGATAGCGTGGCTTTCTTGTCCTTC
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9633.93 Da        Isoelectric Point: 5.1133

>AT125120 WP_176553065.1 NZ_CP040231:c1472144-1471890 [Streptococcus sp. 1643]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKGLSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT125120 NZ_CP040231:c1472144-1471890 [Streptococcus sp. 1643]
ATGGAAGCAGTTCTTTACTCAACATTCCGAAATCATTTAAAAGACTACATGAAGAAGGTAAACGATGAATTTGAGCCTTT
AACGGTGGTCAATAAAAATCCAGATGAGGATATTGTAGTCCTTTCAAAGAGCGAGTGGGATAGTATTCAGGAAACCCTGA
GAATCGCTCAAAACAAGGGACTTTCTGACAAGGTCTTGCGAGGAATGGCTCAAGTCCGAGCTGGAAGTACTCAGGTACAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References