Detailed information of TA system TA125120

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1471632..1472144
• Replicon: chromosome
• Accession: NZ_CP040231
• Organism: Streptococcus sp. 1643

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: FD735_RS07735
• Protein ID: WP_139658890.1
• Coordinates: 1471632..1471886 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: FD735_RS07740
• Protein ID: WP_176553065.1
• Coordinates: 1471890..1472144 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD735_RS07720	1468716..1469030	-	315	WP_002874282.1	DNA-directed RNA polymerase subunit omega	-
FD735_RS07725	1469055..1469681	-	627	WP_000775041.1	guanylate kinase	-
FD735_RS07730	1469816..1471429	-	1614	WP_000404963.1	ribonuclease Y	-
FD735_RS07735	1471632..1471886	-	255	WP_139658890.1	Txe/YoeB family addiction module toxin	Toxin
FD735_RS07740	1471890..1472144	-	255	WP_176553065.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FD735_RS07745	1472277..1473374	-	1098	WP_139658891.1	nucleotidyltransferase	-
FD735_RS07750	1473384..1474130	-	747	WP_081103372.1	class I SAM-dependent methyltransferase	-
FD735_RS07760	1474445..1474798	-	354	WP_139658892.1	ribosome silencing factor	-
FD735_RS07765	1474799..1475392	-	594	WP_139658893.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
FD735_RS07770	1475392..1476021	-	630	WP_000963713.1	nicotinate-nucleotide adenylyltransferase	-
FD735_RS07775	1476074..1476385	-	312	WP_000060169.1	ribosome assembly RNA-binding protein YhbY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10083.49 Da
• Isoelectric Point: 7.9716

>T125120 WP_139658890.1 NZ_CP040231:c1471886-1471632 [Streptococcus sp. 1643]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFSGIGKPEPLKYDYQGAWSRRIDAENRLIYMIDGDSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T125120 NZ_CP040231:c1471886-1471632 [Streptococcus sp. 1643]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTATTGGCAAAACCAAGATAAGAAAACATTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGCGATCCTTTTTCAGGAATAGGTAAACCAGAGCCACTCAAGTATGACTACCAAG
GAGCTTGGTCACGGCGCATTGATGCAGAAAATCGCTTGATTTATATGATAGATGGAGATAGCGTGGCTTTCTTGTCCTTC
AAAGATCATTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9633.93 Da
• Isoelectric Point: 5.1133

>AT125120 WP_176553065.1 NZ_CP040231:c1472144-1471890 [Streptococcus sp. 1643]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKGLSDKVLRGMAQVRAGSTQVH
VIEE

Nucleotide

• Length: 255 bp

>AT125120 NZ_CP040231:c1472144-1471890 [Streptococcus sp. 1643]
ATGGAAGCAGTTCTTTACTCAACATTCCGAAATCATTTAAAAGACTACATGAAGAAGGTAAACGATGAATTTGAGCCTTT
AACGGTGGTCAATAAAAATCCAGATGAGGATATTGTAGTCCTTTCAAAGAGCGAGTGGGATAGTATTCAGGAAACCCTGA
GAATCGCTCAAAACAAGGGACTTTCTGACAAGGTCTTGCGAGGAATGGCTCAAGTCCGAGCTGGAAGTACTCAGGTACAT
GTGATTGAGGAGTGA