Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2779637..2780060 Replicon chromosome
Accession NZ_CP040230
Organism Staphylococcus aureus strain GD1108

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag FD491_RS13645 Protein ID WP_001065091.1
Coordinates 2779637..2779888 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag FD491_RS13650 Protein ID WP_000028422.1
Coordinates 2779878..2780060 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD491_RS13600 2775197..2776117 + 921 WP_138742486.1 recombinase RecT -
FD491_RS13605 2776198..2776815 + 618 WP_071621397.1 MBL fold metallo-hydrolase -
FD491_RS13610 2776816..2777286 + 471 WP_000934764.1 single-stranded DNA-binding protein -
FD491_RS13615 2777316..2778200 + 885 WP_000148316.1 DnaD domain protein -
FD491_RS13620 2778207..2778425 + 219 WP_000338530.1 hypothetical protein -
FD491_RS13625 2778434..2778838 + 405 WP_000401960.1 RusA family crossover junction endodeoxyribonuclease -
FD491_RS13630 2778851..2779219 + 369 WP_000101274.1 hypothetical protein -
FD491_RS13635 2779223..2779465 + 243 WP_000131366.1 hypothetical protein -
FD491_RS13640 2779477..2779644 + 168 WP_001624242.1 hypothetical protein -
FD491_RS13645 2779637..2779888 + 252 WP_001065091.1 DUF1024 family protein Toxin
FD491_RS13650 2779878..2780060 + 183 WP_000028422.1 hypothetical protein Antitoxin
FD491_RS13655 2780053..2780595 + 543 WP_000185660.1 dUTP pyrophosphatase -
FD491_RS13660 2780632..2780838 + 207 WP_000195803.1 DUF1381 domain-containing protein -
FD491_RS13665 2780835..2781221 + 387 WP_000592207.1 hypothetical protein -
FD491_RS13670 2781218..2781367 + 150 WP_000595265.1 transcriptional activator RinB -
FD491_RS13675 2781367..2781567 + 201 WP_000265043.1 DUF1514 family protein -
FD491_RS13680 2781595..2782011 + 417 WP_000590122.1 hypothetical protein -
FD491_RS13685 2782243..2782542 + 300 WP_000988336.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb 2754500..2782542 28042


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T125119 WP_001065091.1 NZ_CP040230:2779637-2779888 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T125119 NZ_CP040230:2779637-2779888 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT125119 WP_000028422.1 NZ_CP040230:2779878-2780060 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT125119 NZ_CP040230:2779878-2780060 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References