Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2628835..2629098 Replicon chromosome
Accession NZ_CP040230
Organism Staphylococcus aureus strain GD1108

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag FD491_RS12825 Protein ID WP_001802298.1
Coordinates 2628835..2628939 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2628934..2629098 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD491_RS12800 2624734..2625342 + 609 WP_000101715.1 TIR domain-containing protein -
FD491_RS12805 2625632..2626414 + 783 WP_000908191.1 ABC transporter ATP-binding protein -
FD491_RS12810 2626482..2627339 + 858 WP_000370942.1 Cof-type HAD-IIB family hydrolase -
FD491_RS12815 2627469..2627561 - 93 WP_000220902.1 hypothetical protein -
FD491_RS12820 2627997..2628155 - 159 WP_001792784.1 hypothetical protein -
FD491_RS12825 2628835..2628939 + 105 WP_001802298.1 hypothetical protein Toxin
- 2628934..2629098 - 165 - - Antitoxin
FD491_RS12830 2629437..2630528 - 1092 WP_000495673.1 hypothetical protein -
FD491_RS12835 2630794..2631774 - 981 WP_000019735.1 CDF family zinc efflux transporter CzrB -
FD491_RS12840 2631776..2632096 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
FD491_RS12845 2632248..2632913 + 666 WP_001024099.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T125113 WP_001802298.1 NZ_CP040230:2628835-2628939 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T125113 NZ_CP040230:2628835-2628939 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT125113 NZ_CP040230:c2629098-2628934 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References