125110

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1183015..1183429 Replicon chromosome
Accession NZ_CP040230
Organism Staphylococcus aureus strain GD1108

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FD491_RS05870 Protein ID WP_110166336.1
Coordinates 1183178..1183429 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FD491_RS05865 Protein ID WP_000028424.1
Coordinates 1183015..1183188 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD491_RS05820 1178946..1180154 - 1209 WP_001807202.1 PBSX family phage terminase large subunit -
FD491_RS05825 1180147..1180641 - 495 WP_000594085.1 hypothetical protein -
FD491_RS05830 1180993..1181394 - 402 WP_000286968.1 hypothetical protein -
FD491_RS05835 1181395..1181568 - 174 WP_000166075.1 transcriptional activator RinB -
FD491_RS05840 1181565..1181771 - 207 WP_000195791.1 DUF1381 domain-containing protein -
FD491_RS05845 1181768..1182013 - 246 WP_138742453.1 hypothetical protein -
FD491_RS05850 1182050..1182556 - 507 WP_001061842.1 dUTPase -
FD491_RS05855 1182571..1182732 - 162 WP_000889683.1 hypothetical protein -
FD491_RS05860 1182733..1183014 - 282 WP_000454994.1 hypothetical protein -
FD491_RS05865 1183015..1183188 - 174 WP_000028424.1 hypothetical protein Antitoxin
FD491_RS05870 1183178..1183429 - 252 WP_110166336.1 DUF1024 family protein Toxin
FD491_RS05875 1183444..1183692 - 249 WP_078090474.1 phi PVL orf 51-like protein -
FD491_RS05880 1183698..1183946 - 249 WP_064127572.1 DUF3310 domain-containing protein -
FD491_RS05885 1183946..1184305 - 360 WP_138742452.1 hypothetical protein -
FD491_RS05890 1184317..1184574 - 258 WP_054249697.1 helix-turn-helix transcriptional regulator -
FD491_RS05895 1184575..1184760 - 186 WP_031918004.1 DUF3113 family protein -
FD491_RS05900 1184765..1185169 - 405 WP_138742451.1 DUF1064 domain-containing protein -
FD491_RS05905 1185180..1185401 - 222 WP_138742450.1 DUF3269 family protein -
FD491_RS05910 1185414..1185572 - 159 WP_000628837.1 hypothetical protein -
FD491_RS05915 1185569..1186354 - 786 WP_000443353.1 ATP-binding protein -
FD491_RS05920 1186367..1187188 - 822 WP_138742449.1 phage replisome organizer N-terminal domain-containing protein -
FD491_RS05925 1187160..1187855 - 696 WP_113555202.1 hypothetical protein -
FD491_RS05930 1187867..1188307 - 441 WP_113555201.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 1135743..1195655 59912


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9445.35 Da        Isoelectric Point: 3.9476

>T125110 WP_110166336.1 NZ_CP040230:c1183429-1183178 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T125110 NZ_CP040230:c1183429-1183178 [Staphylococcus aureus]
ATGAATAATCGTGAACAAATTGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAGAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTGGTCTATAAATATGAGGAGGAACAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT125110 WP_000028424.1 NZ_CP040230:c1183188-1183015 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT125110 NZ_CP040230:c1183188-1183015 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCCGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AAGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References