Detailed information of TA system TA125105

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF3/-
• Location: 20040..20488
• Replicon: chromosome
• Accession: NZ_CP040230
• Organism: Staphylococcus aureus strain GD1108

Toxin (Protein)

• Gene name: holin
• Uniprot ID: A0A853P973
• Locus tag: FD491_RS00120
• Protein ID: WP_000387656.1
• Coordinates: 20186..20488 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	20040..20106 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD491_RS00090	15141..18821	+	3681	WP_000582140.1	hypothetical protein	-
FD491_RS00095	18808..18960	+	153	WP_001181555.1	hypothetical protein	-
FD491_RS00100	19007..19294	+	288	WP_001040257.1	hypothetical protein	-
FD491_RS00105	19352..19648	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
FD491_RS00110	19840..19987	+	148	Protein_21	putative holin-like toxin	-
FD491_RS00115	20031..20135	-	105	Protein_22	hypothetical protein	-
-	20040..20106	-	67	NuclAT_0	-	Antitoxin
-	20040..20106	-	67	NuclAT_0	-	Antitoxin
-	20040..20106	-	67	NuclAT_0	-	Antitoxin
-	20040..20106	-	67	NuclAT_0	-	Antitoxin
FD491_RS00120	20186..20488	+	303	WP_000387656.1	phage holin	Toxin
FD491_RS00125	20500..21954	+	1455	WP_000930259.1	N-acetylmuramoyl-L-alanine amidase	-
FD491_RS00130	22049..22498	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
FD491_RS00135	23183..23533	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
FD491_RS00140	23586..23846	-	261	WP_001791826.1	hypothetical protein	-
FD491_RS00145	24157..24336	-	180	WP_000669789.1	hypothetical protein	-
FD491_RS00150	24658..24905	-	248	Protein_29	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	chp / scn	1..23533	23532

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (3-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11177.94 Da
• Isoelectric Point: 9.6587

>T125105 WP_000387656.1 NZ_CP040230:20186-20488 [Staphylococcus aureus]
MEAKVMARYVVLILALVNQFLANKGISPIPVDEESISSIILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T125105 NZ_CP040230:20186-20488 [Staphylococcus aureus]
ATGGAAGCAAAAGTAATGGCAAGATACGTTGTATTGATTTTAGCGTTAGTCAATCAGTTTTTAGCGAATAAAGGTATAAG
CCCGATACCAGTAGATGAAGAAAGTATTTCATCGATCATCTTAACAGTTATTGCTTTATACACTACGTATAAAGACAATC
CAACATCACAAGAAGGACGTTGGGCGAATCAAAAATTAAAGAAATATAAAGCAGAAAGTAAATATAGAAAAGCAACAGGA
CAAGCACCTATCAAAGAAGTGATGACACCTACAAATATGAACGACACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 67 bp

>AT125105 NZ_CP040230:c20106-20040 [Staphylococcus aureus]
ATAAATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCT

Structures

Toxin

• AlphaFold DB: A0A853P973

Antitoxin