Detailed information of TA system TA125102

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2138370..2138587
• Replicon: chromosome
• Accession: NZ_CP040229
• Organism: Staphylococcus aureus strain GD487

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: FD482_RS10535
• Protein ID: WP_001802298.1
• Coordinates: 2138483..2138587 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2138370..2138425 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD482_RS10515	2134509..2135174	-	666	WP_001024099.1	SDR family oxidoreductase	-
FD482_RS10520	2135326..2135646	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
FD482_RS10525	2135648..2136628	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
FD482_RS10530	2136894..2137985	+	1092	WP_000495673.1	hypothetical protein	-
-	2138370..2138425	+	56	-	-	Antitoxin
FD482_RS10535	2138483..2138587	-	105	WP_001802298.1	hypothetical protein	Toxin
FD482_RS10540	2139267..2139425	+	159	WP_001792784.1	hypothetical protein	-
FD482_RS10545	2139861..2139953	+	93	WP_000220902.1	hypothetical protein	-
FD482_RS10550	2140083..2140940	-	858	WP_000370942.1	Cof-type HAD-IIB family hydrolase	-
FD482_RS10555	2141008..2141790	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
FD482_RS10560	2142080..2142688	-	609	WP_000101714.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T125102 WP_001802298.1 NZ_CP040229:c2138587-2138483 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T125102 NZ_CP040229:c2138587-2138483 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT125102 NZ_CP040229:2138370-2138425 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin