Detailed information of TA system TA125097

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 1275872..1276179
• Replicon: chromosome
• Accession: NZ_CP040229
• Organism: Staphylococcus aureus strain GD487

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: FD482_RS06120
• Protein ID: WP_011447039.1
• Coordinates: 1275872..1276048 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1276038..1276179 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD482_RS06100	1273702..1273854	+	153	WP_001000058.1	hypothetical protein	-
FD482_RS06105	1273900..1274187	+	288	WP_001262621.1	hypothetical protein	-
FD482_RS06110	1274243..1274617	+	375	WP_000340977.1	hypothetical protein	-
FD482_RS06115	1274990..1275763	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
FD482_RS06120	1275872..1276048	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	1276038..1276179	-	142	-	-	Antitoxin
FD482_RS06130	1276260..1276514	+	255	WP_000611512.1	phage holin	-
FD482_RS06135	1276526..1277281	+	756	WP_000861038.1	CHAP domain-containing protein	-
FD482_RS06140	1277472..1277963	+	492	WP_000920038.1	staphylokinase	-
FD482_RS06145	1278614..1278949	+	336	Protein_1204	SH3 domain-containing protein	-
FD482_RS06150	1279460..1279810	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
FD482_RS06155	1279863..1280123	-	261	WP_001791826.1	hypothetical protein	-
FD482_RS06160	1280434..1280613	-	180	WP_000669791.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T125097 WP_011447039.1 NZ_CP040229:1275872-1276048 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T125097 NZ_CP040229:1275872-1276048 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 142 bp

>AT125097 NZ_CP040229:c1276179-1276038 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• PDB: 7NS1

Antitoxin